D
Donghern Kim
Researcher at University of Kentucky
Publications - 29
Citations - 1300
Donghern Kim is an academic researcher from University of Kentucky. The author has contributed to research in topics: Reactive oxygen species & Carcinogenesis. The author has an hindex of 21, co-authored 29 publications receiving 1055 citations. Previous affiliations of Donghern Kim include Chonnam National University.
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Journal ArticleDOI
Quercitrin protects skin from UVB-induced oxidative damage.
Yuanqin Yin,Wenqi Li,Young-Ok Son,Lijuan Sun,Jian Lu,Donghern Kim,Xin Wang,Hua Yao,Lei Wang,Poyil Pratheeshkumar,Andrew Hitron,Jia Luo,Ning Gao,Xianglin Shi,Zhuo Zhang +14 more
TL;DR: Quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure.
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Luteolin Inhibits Human Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2-Mediated Angiogenesis
Poyil Pratheeshkumar,Young-Ok Son,Amit Budhraja,Xin Wang,Songze Ding,Lei Wang,Andrew Hitron,Jeong-Chae Lee,Donghern Kim,Sasidharan Padmaja Divya,Gang Chen,Zhuo Zhang,Jia Luo,Xianglin Shi +13 more
TL;DR: The findings demonstrate that luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.
Journal ArticleDOI
Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways.
Poyil Pratheeshkumar,Young-Ok Son,Sasidharan Padmaja Divya,Ram Vinod Roy,John Andrew Hitron,Lei Wang,Donghern Kim,Jin Dai,Padmaja Asha,Zhuo Zhang,Yitao Wang,Xianglin Shi +11 more
TL;DR: The results indicate that luteolin protects BEAS-2B cells from Cr(VI)-induced carcinogenesis by scavenging ROS and modulating multiple cell signaling mechanisms that are linked to ROS.
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Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway.
Sasidharan Padmaja Divya,Poyil Pratheeshkumar,Young-Ok Son,Ram Vinod Roy,John Andrew Hitron,Donghern Kim,Jin Dai,Lei Wang,Padmaja Asha,Bin Huang,Mei Xu,Jia Luo,Zhuo Zhang +12 more
TL;DR: The results show that chronic arsenic exposure significantly decreased insulin-stimulated glucose uptake (ISGU) in correlation with reduced expression of insulin-regulated glucose transporter type 4 (Glut4) and suggest that Sirt3/FOXO3a/MnSOD signaling plays a significant role in the inhibition of ISGU induced by chronic arsenic Exposure.
Journal ArticleDOI
A Cancer-Specific Variant of the SLCO1B3 Gene Encodes a Novel Human Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Localized Mainly in the Cytoplasm of Colon and Pancreatic Cancer Cells
Nilay Thakkar,Kyung Bo Kim,Eun Ryoung Jang,Songhee Han,Kyunghwa Kim,Donghern Kim,Nipun B. Merchant,A. Craig Lockhart,Wooin Lee +8 more
TL;DR: It is demonstrated that colon and pancreatic cancer cells express variant forms of OATP1B3 with only limited transport activity and different subcellular localization compared to OATp 1B3 WT.