R
Ram Vinod Roy
Researcher at University of Kentucky
Publications - 15
Citations - 576
Ram Vinod Roy is an academic researcher from University of Kentucky. The author has contributed to research in topics: Carcinogenesis & Oxidative stress. The author has an hindex of 11, co-authored 14 publications receiving 466 citations.
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Journal ArticleDOI
Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways.
Poyil Pratheeshkumar,Young-Ok Son,Sasidharan Padmaja Divya,Ram Vinod Roy,John Andrew Hitron,Lei Wang,Donghern Kim,Jin Dai,Padmaja Asha,Zhuo Zhang,Yitao Wang,Xianglin Shi +11 more
TL;DR: The results indicate that luteolin protects BEAS-2B cells from Cr(VI)-induced carcinogenesis by scavenging ROS and modulating multiple cell signaling mechanisms that are linked to ROS.
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Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway.
Sasidharan Padmaja Divya,Poyil Pratheeshkumar,Young-Ok Son,Ram Vinod Roy,John Andrew Hitron,Donghern Kim,Jin Dai,Lei Wang,Padmaja Asha,Bin Huang,Mei Xu,Jia Luo,Zhuo Zhang +12 more
TL;DR: The results show that chronic arsenic exposure significantly decreased insulin-stimulated glucose uptake (ISGU) in correlation with reduced expression of insulin-regulated glucose transporter type 4 (Glut4) and suggest that Sirt3/FOXO3a/MnSOD signaling plays a significant role in the inhibition of ISGU induced by chronic arsenic Exposure.
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Nrf2/p62 Signaling in Apoptosis Resistance and Its Role in Cadmium-induced Carcinogenesis *
Young-Ok Son,Poyil Pratheeshkumar,Ram Vinod Roy,John Andrew Hitron,Lei Wang,Zhuo Zhang,Xianglin Shi +6 more
TL;DR: This study demonstrates that cadmium-transformed cells have acquired autophagy deficiency, leading to constitutive p62 and Nrf2 overexpression, which results in a decrease in ROS generation, apoptosis resistance, and tumorigenesis.
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Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin
Poyil Pratheeshkumar,Young-Ok Son,Xin Wang,Sasidharan Padmaja Divya,Binoy Joseph,John Andrew Hitron,Lei Wang,Donghern Kim,Yuanqin Yin,Ram Vinod Roy,Jian Lu,Zhuo Zhang,Yitao Wang,Xianglin Shi +13 more
TL;DR: C3G can provide substantial protection against the adverse effects of UVB radiation by modulating UVB-induced MAP kinase and NF-κB signaling pathways.
Journal ArticleDOI
Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-κB signaling pathways in SKH-1 mice skin.
Sasidharan Padmaja Divya,Xin Wang,Poyil Pratheeshkumar,Young-Ok Son,Ram Vinod Roy,Donghern Kim,Jin Dai,John Andrew Hitron,Lei Wang,Padmaja Asha,Xianglin Shi,Zhuo Zhang +11 more
TL;DR: Blackberry extract protects from UVB-induced oxidative damage and inflammation by modulating MAP kinase and NF-κB signaling pathways, and results show that BBE suppressedUVB- induced hyperplasia and reduced infiltration of inflammatory cells in the SKH-1 hairless mice skin.