Dongyang Zhang

TL;DR: An efficient one-step conversion of isolated mouse and human astrocytes to functional neurons by depleting the RNA-binding protein PTB is reported, identifying a potentially powerful and clinically feasible approach to treating neurodegeneration by replacing lost neurons.

TL;DR: This method demonstrates the successful spatiotemporal photoregulation of gene expression with single-cell precision and provides a modular and efficient approach for developing synthetic gene regulatory circuits, biotechnological applications, and therapeutic discovery.

TL;DR: This high-yielding non-enzymatic synthesis of natural diacylphospholipids in water opens up new routes for lipid synthesis in artificial cells and sheds light on the origin and evolution of cellular membranes.

TL;DR: Sequential photo-activation of two mRNAs enabled precise optical control of translation of two unique transcripts and will serve as a powerful tool in future biological studies that require controlling translation of multiple transcripts with high spatiotemporal resolution.

TL;DR: This work employed a two-step strategy for functionalization of the mod-mRNA to highlight the therapeutic potential of this new methodology, and envision that this novel and facile labeling methodology of mod-RNA will have great potential in decorating both coding and noncoding therapeutic RNAs with a variety of diagnostic and functional moieties.