J
Jing Hu
Researcher at University of California, San Diego
Publications - 25
Citations - 1613
Jing Hu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Histone code & Chromatin immunoprecipitation. The author has an hindex of 16, co-authored 24 publications receiving 1186 citations. Previous affiliations of Jing Hu include Wuhan University & University of Electronic Science and Technology of China.
Papers
More filters
Journal ArticleDOI
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.
Kimberly Martinod,Melanie Demers,Melanie Demers,Tobias A. Fuchs,Tobias A. Fuchs,Siu Ling Wong,Siu Ling Wong,Alexander Brill,Alexander Brill,Maureen Gallant,Jing Hu,Yanming Wang,Denisa D. Wagner,Denisa D. Wagner +13 more
TL;DR: In this article, the authors adopted a stenosis model of deep vein thrombosis and analyzed venous thrombi in peptidylarginine deiminase 4 (PAD4)-deficient mice that cannot citrullinate histones, a process required for chromatin decondensation and NET formation.
Journal ArticleDOI
Reversing a model of Parkinson’s disease with in situ converted nigral neurons
Hao Qian,Xinjiang Kang,Jing Hu,Jing Hu,Dongyang Zhang,Zhengyu Liang,Fan Meng,Xuan Zhang,Yuanchao Xue,Yuanchao Xue,Roy Maimon,Roy Maimon,Steven F. Dowdy,Neal K. Devaraj,Zhuan Zhou,William C. Mobley,Don W. Cleveland,Don W. Cleveland,Xiang-Dong Fu +18 more
TL;DR: An efficient one-step conversion of isolated mouse and human astrocytes to functional neurons by depleting the RNA-binding protein PTB is reported, identifying a potentially powerful and clinically feasible approach to treating neurodegeneration by replacing lost neurons.
Journal ArticleDOI
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations
Liang Chen,Jia-Yu Chen,Yi-Jou Huang,Ying Gu,Jinsong Qiu,Hao Qian,Changwei Shao,Xuan Zhang,Jing Hu,Hairi Li,Shunmin He,Yu Zhou,Omar Abdel-Wahab,Dong-Er Zhang,Xiang-Dong Fu +14 more
TL;DR: It is demonstrated that enhanced R-loops, opposite to the expectation from gained RNA binding with mutant SRSF2, result from impaired transcription pause release because the mutant protein loses its ability to extract the RNA polymerase II C-terminal domain (CTD) kinase-the positive transcription elongation factor complex (P-TEFb)-from the 7SK complex.
Journal ArticleDOI
Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity
Yuji Wang,Yuji Wang,Pingxin Li,Shu Wang,Jing Hu,Xiangyun Amy Chen,Jianhui Wu,Jianhui Wu,Megan Fisher,Kira Oshaben,Na Zhao,Ying Gu,Dong Wang,Gong Chen,Yanming Wang +14 more
TL;DR: PAD4 regulates the mTORC1 signaling pathway and that PAD inhibitors are potential anticancer reagents that activate tumor suppressor gene expression alone or in combination with histone deacetylase inhibitors.
Journal ArticleDOI
Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells
Yuanchao Xue,Yuanchao Xue,Hao Qian,Jing Hu,Bing Zhou,Yu Zhou,Xihao Hu,Aziz Karakhanyan,Zhiping P. Pang,Xiang-Dong Fu +9 more
TL;DR: It is reported that the functionality requires sequential inactivation of PTB and the PTB paralog nPTB in HAFs, and suggests that two separate gatekeepers control neuronal conversion and maturation and consecutively overcoming these gatekeepers enables deterministic reprogramming of H AFs into functional neurons.