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Donovan Maust
Researcher at National Institutes of Health
Publications - 1
Citations - 785
Donovan Maust is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Ubiquitin ligase & Cellular differentiation. The author has an hindex of 1, co-authored 1 publications receiving 762 citations.
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Mind Bomb Is a Ubiquitin Ligase that Is Essential for Efficient Activation of Notch Signaling by Delta
Motoyuki Itoh,Cheol-Hee Kim,Gregory R. Palardy,Takaya Oda,Yun-Jin Jiang,Donovan Maust,Sang-Yeob Yeo,Kevin L. Lorick,Gavin J. Wright,Linda Ariza-McNaughton,Allan M. Weissman,Julian Lewis,Settara C. Chandrasekharappa,Ajay B. Chitnis +13 more
TL;DR: Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells, and observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocyTosis of the Notch extracellular domain by the signalingcell.