Kevin L. Lorick

TL;DR: It is suggested that a large number of RING finger-containing proteins, with otherwise diverse structures and functions, may play previously unappreciated roles in modulating protein levels via ubiquitination.

TL;DR: Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells, and observations support a model for Notch activation where the Delta-Notch interaction is followed by endocytosis of Delta and transendocyTosis of the Notch extracellular domain by the signalingcell.

TL;DR: PYR-41 and related pyrazones provide proof of principle for the capacity to differentially kill transformed cells, suggesting the potential for E1 inhibitors as therapeutics in cancer and can also be valuable tools for studying ubiquitylation.

TL;DR: Recent advances in the understanding of RING finger and Ringer finger-related E3s with emphasis on BRCA1 and the tumor autocrine motility factor receptor are summarized and the potential for components of the ubiquitin pathway for proteasomal degradation as molecular targets are discussed.

TL;DR: It is described that the cellular levels of AIB1 are controlled through regulated proteasomal degradation, and a model is proposed whereby signals promoted by changes in the cellular milieu initiate E6AP-mediated proteasome degradation ofAIB1 and thus contribute to the control of steady-state levels of this protein.