K
Klaus-Jürgen Petzke
Publications - 4
Citations - 312
Klaus-Jürgen Petzke is an academic researcher. The author has contributed to research in topics: Lipogenesis & Flux (metabolism). The author has an hindex of 4, co-authored 4 publications receiving 284 citations.
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Journal ArticleDOI
Telomerase deficiency impairs glucose metabolism and insulin secretion.
Doreen Kuhlow,Simone Florian,von Figura G,Sandra Weimer,Schulz N,Klaus-Jürgen Petzke,Kim Zarse,Andreas Pfeiffer,Rudolph Kl,Michael Ristow +9 more
TL;DR: In this article, the Terc subunit of the telomerase was found to exhibit impaired glucose tolerance in young adult mice, which is caused by impaired glucose-stimulated insulin secretion (GSIS) from pancreatic islets.
Journal ArticleDOI
Impairment of fat oxidation under high- vs. low-glycemic index diet occurs before the development of an obese phenotype
Frank Isken,Susanne Klaus,Klaus-Jürgen Petzke,Christoph Loddenkemper,Andreas Pfeiffer,Martin O. Weickert +5 more
TL;DR: Long-term high-GI feeding resulted in an obese, insulin-resistant, and metabolically inflexible phenotype in obesity-prone C57BL/6J mice, indicating a potentially causal involvement.
Journal ArticleDOI
Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux
Mario Ost,Susanne Keipert,Evert M. van Schothorst,Verena Donner,Inge van der Stelt,Anna P. Kipp,Klaus-Jürgen Petzke,Mariona Jové,Reinald Pamplona,Manuel Portero-Otin,Jaap Keijer,Susanne Klaus +11 more
TL;DR: A detailed metabolic reprogramming profile associated with mitochondrial perturbations in SM is described, triggering an increased protein turnover and amino acid metabolism with induced biosynthetic serine/1‐carbon/glycine pathway and the longevity‐promoting polyamine spermidine as well as the trans‐sulfuration pathway.
Journal ArticleDOI
Modulation of amino acid metabolic signatures by supplemented isoenergetic diets differing in protein and cereal fiber content.
John Hattersley,Andreas Pfeiffer,Michael Roden,Klaus-Jürgen Petzke,D Hoffmann,Natalia Rudovich,Harpal S. Randeva,Manu Vatish,Martin A. Osterhoff,Ozlem Goegebakan,Silke Hornemann,Peter Nowotny,Jürgen Machann,Johannes Hierholzer,Christian von Loeffelholz,Matthias Möhlig,Ayman M. Arafat,Martin O. Weickert,Martin O. Weickert +18 more
TL;DR: It is demonstrated that relatively short-term isoenergetic changes in the diet significantly alter the relation of AA signatures with IR, with possible implications on the determination and treatment of diabetes risk.