Telomerase deficiency impairs glucose metabolism and insulin secretion.
Doreen Kuhlow,Simone Florian,von Figura G,Sandra Weimer,Schulz N,Klaus-Jürgen Petzke,Kim Zarse,Andreas Pfeiffer,Rudolph Kl,Michael Ristow +9 more
- Vol. 2, Iss: 10, pp 650-658
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TLDR
In this article, the Terc subunit of the telomerase was found to exhibit impaired glucose tolerance in young adult mice, which is caused by impaired glucose-stimulated insulin secretion (GSIS) from pancreatic islets.Abstract:
Reduced telomere length and impaired telomerase activity have been linked to several diseases associated with senescence and aging. However, a causal link to metabolic disorders and in particular diabetes mellitus is pending. We here show that young adult mice which are deficient for the Terc subunit of telomerase exhibit impaired glucose tolerance. This is caused by impaired glucose-stimulated insulin secretion (GSIS) from pancreatic islets, while body fat content, energy expenditure and insulin sensitivity were found to be unaltered. The impaired secretion capacity for insulin is due to reduced islet size which is linked to an impaired replication capacity of insulin-producing beta-cells in Terc-deficient mice. Taken together, telomerase deficiency and hence short telomeres impair replicative capacity of pancreatic beta-cells to cause impaired insulin secretion and glucose intolerance, mechanistically defining diabetes mellitus as an aging-associated disorder.read more
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Telomerase Gene Therapy in Adult and Old Mice Delays Aging and Increases Longevity Without Increasing Cancer
Bruno Bernardes de Jesus,Elsa Vera,Kerstin Schneeberger,Agueda M. Tejera,Eduard Ayuso,Fatima Bosch,Maria A. Blasco +6 more
TL;DR: A proof‐of‐principle of a role of TERT in delaying physiological aging and extending longevity in normal mice through a telomerase‐based treatment is formed, and the feasibility of anti‐aging gene therapy is demonstrated.
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Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis.
Peter Willeit,Julia Raschenberger,Emma E Heydon,Sotirios Tsimikas,Margot Haun,Agnes Mayr,Siegfried Weger,Joseph L. Witztum,Adam S. Butterworth,Johann Willeit,Florian Kronenberg,Stefan Kiechl +11 more
TL;DR: Low RTL is independently associated with the risk of incident type 2 diabetes mellitus and future studies should implement methods correcting for within-person variability in RTL, to avoid regression dilution biases.
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Answering the ultimate question “What is the Proximal Cause of Aging?”
TL;DR: The essence of aging turns out to be so startling that the theory cannot be instantly accepted and any possible arguments are raised for its disposal, suggesting that these arguments actually support a new theory.
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Telomere length variations in aging and age-related diseases.
TL;DR: Ongoing and progressive research in the field of telomere length dynamics has proved that aging and age-related diseases apart from having a synergistic effect on telomeres length were also found to effect telomer length independently also.
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D -Glucosamine supplementation extends life span of nematodes and of ageing mice
Sandra Weimer,Josephine Priebs,Doreen Kuhlow,Marco Groth,Steffen Priebe,Johannes Mansfeld,Troy L. Merry,Sébastien Dubuis,Beate Laube,Andreas Pfeiffer,Tim J. Schulz,Reinhard Guthke,Matthias Platzer,Nicola Zamboni,Kim Zarse,Michael Ristow +15 more
TL;DR: Evidence is provided that GlcN extends life span in evolutionary distinct species by mimicking a low-carbohydrate diet and promotes increased formation of mitochondrial reactive oxygen species (ROS) culminating in increased expression of the nematodal amino acid-transporter 1 (aat-1) gene.
References
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