Doretta Caramaschi

TL;DR: An updated overview of covariation between individual differences in stress physiology and behavioural profiles, here called personalities, across different species and taxa is provided, consider its functional significance and present working hypotheses for how behavioural and physiological responses to stress might be causally linked.

TL;DR: Findings indicate that state of SLC6A4 promoter methylation is altered in peripheral white blood cells of individuals with physical aggression during childhood, which supports the relevance of peripheral DNA methylation for brain function and suggests that peripheral SLC 6A4DNA methylation could be a marker of central 5-HT function.

TL;DR: The results strengthen the validity of the serotonin-deficiency hypothesis of aggression and suggest that chronic exaggerated activity of the 5- HT(1A) receptor may be a causative link in the neural cascade of events leading to 5-HT hypofunction in aggressive individuals.

TL;DR: It is concluded that social experience changes prefrontal cortex neurochemistry and elicits pathologically aggressive phenotypes, and serotonin levels in the prefrontal cortex were significantly lower in SAL than in LAL whereas dopamine turnover was significantly higher, compared to CTR mice.

TL;DR: A revised view is presented on the key role of central serotonergic (auto)regulatory mechanisms in this transition of normal aggression into violence.