Douglas H. Sieglaff

TL;DR: The data indicate that ALS monocytes are skewed toward a proinflammatory state in the peripheral circulation and may play a role in ALS disease progression, especially in rapidly progressing patients.

TL;DR: It is proposed that SIRT1 is a gene-specific TRβ1 co-regulator and TR β1/SIRT1 interactions could play important roles in regulation of liver metabolic response and open possibilities for modulation of subsets of TR target genes with drugs that influence the Sirt1 pathway.

TL;DR: It is shown that saturating concentrations of the main active form of TH, T(3), and the prototype STRM GC-1 induce identical gene sets in livers of euthyroid and hypothyroid mice and a human cultured hepatoma cell line that only expresses TRβ, HepG2.

TL;DR: It is proposed thatTRs cooperate with KLF9 to regulate hepatocyte proliferation and differentiation and early stages of organogenesis and that TRs exert widespread and important influences on ESC biology.

TL;DR: It is suggested that gene-selective effects on mechanism of TR action highlight differences in TR subtype function that emerge in the environment of specific genes, including effects on magnitude of response to TR +/− T3, TR regulation patterns and T3 dose response.