A
Aleksandra Cvoro
Researcher at Houston Methodist Hospital
Publications - 27
Citations - 1030
Aleksandra Cvoro is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Receptor & Glucocorticoid receptor. The author has an hindex of 14, co-authored 26 publications receiving 922 citations. Previous affiliations of Aleksandra Cvoro include Cornell University & University of São Paulo.
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Journal ArticleDOI
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists
Marcelo Vizoná Liberato,Alessandro S. Nascimento,Stephen D. Ayers,Jean Z. Lin,Aleksandra Cvoro,Rodrigo L. Silveira,Leandro Martínez,Paulo C. T. Souza,Daniel M. Saidemberg,Tuo Deng,Angela Angelica Amato,Marie Togashi,Willa A. Hsueh,Kevin J. Phillips,Mario Sergio Palma,Francisco de Assis Rocha Neves,Munir S. Skaf,Paul Webb,Igor Polikarpov +18 more
TL;DR: It is proposed that MCFA assay-specific actions are linked to their unique binding mode and suggest that it may be possible to identify selective PPARγ modulators with useful clinical profiles among natural products.
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3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
Anastasia Petrova,Anna Celli,Laureen Jacquet,Dimitra Dafou,Debra Crumrine,Melanie Hupe,Matthew Arno,Carl Hobbs,Aleksandra Cvoro,Panagiotis Karagiannis,Liani Devito,Richard Sun,Lillian C. Adame,Robert Vaughan,John A. McGrath,Theodora M. Mauro,Dusko Ilic +16 more
TL;DR: The generation of human epidermal equivalents (HEEs) from human embryonic stem cells and induced pluripotent stem cells are demonstrated, which are structurally similar to native epidermis, with a functional permeability barrier.
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Mode of peroxisome proliferator-activated receptor γ activation by luteolin.
Ana C. Puhl,Amanda Bernardes,Rodrigo L. Silveira,Jing Yuan,Jessica L. O. Campos,Daniel M. Saidemberg,Mario Sergio Palma,Aleksandra Cvoro,Stephen D. Ayers,Paul Webb,Peter S. Reinach,Munir S. Skaf,Igor Polikarpov +12 more
TL;DR: The authors showed that luteolin exhibits weak partial agonist/antagonist activity in transfections, inhibits several PPARγ target genes in 3T3-L1 cells (LPL, ORL1, and CEBPα), but activates GLUT4 to a similar degree as rosiglitazone, implying gene-specific partial agonism.
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Mechanisms of Peroxisome Proliferator Activated Receptor γ Regulation by Non-steroidal Anti-inflammatory Drugs:
Ana C. Puhl,Flora A. Milton,Aleksandra Cvoro,Douglas H. Sieglaff,Jéssica C.L. Campos,Amanda Bernardes,Carly S. Filgueira,Jan Lammel Lindemann,Tuo Deng,Francisco de Assis Rocha Neves,Igor Polikarpov,Paul Webb +11 more
TL;DR: Assessment of NSAID activities in PPARγ-dependent 3T3-L1 cells reveals that NSAIDs display adipogenic activities and exclusively regulate PPARβ-dependent target genes in a manner that is consistent with their observed binding modes.
Journal ArticleDOI
SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions.
Ji Ho Suh,Douglas H. Sieglaff,Aijun Zhang,Xuefeng Xia,Aleksandra Cvoro,Glenn E. Winnier,Paul Webb +6 more
TL;DR: It is proposed that SIRT1 is a gene-specific TRβ1 co-regulator and TR β1/SIRT1 interactions could play important roles in regulation of liver metabolic response and open possibilities for modulation of subsets of TR target genes with drugs that influence the Sirt1 pathway.