D
Dusko Ilic
Researcher at King's College London
Publications - 208
Citations - 14204
Dusko Ilic is an academic researcher from King's College London. The author has contributed to research in topics: Stem cell & Regenerative medicine. The author has an hindex of 47, co-authored 188 publications receiving 13276 citations. Previous affiliations of Dusko Ilic include University of Cambridge & Kumamoto University.
Papers
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Journal ArticleDOI
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
Dusko Ilic,Yasuhide Furuta,Satoshi Kanazawa,Naoki Takeda,Kenji Sobue,Norio Nakatsuji,S Nomura,Jiro Fujimoto,Masato Okada,Tadashi Yamamoto +9 more
TL;DR: Surprisingly, the number of focal adhesions was increased in FAK-deficient cells, suggesting that FAK may be involved in the turnover of focalAdhesion contacts during cell migration.
FAK integrates growth-factor and integrin signals to promote cell
David J. Sieg,Christof R. Hauck,Dusko Ilic,Candice K. Klingbeil,Erik Schaefer,David D. Schlaepfer +5 more
TL;DR: In this article, the authors show that cells lacking focal adhesion kinase (FAK) are refractory to motility signals from platelet-derived and epidermal growth factors (PDGF and EGF respectively), and that stable re-expression of FAK rescues these defects.
Journal ArticleDOI
FAK integrates growth-factor and integrin signals to promote cell migration
David J. Sieg,Christof R. Hauck,Dusko Ilic,Candice K. Klingbeil,Erik Schaefer,Caroline H. Damsky,David D. Schlaepfer +6 more
TL;DR: It is shown that cells lacking focal adhesion kinase (FAK) are refractory to motility signals from platelet-derived and epidermal growth factors (PDGF and EGF respectively), and that stable re-expression of FAK rescues these defects.
Journal ArticleDOI
Differential regulation of cell motility and invasion by FAK
Datsun A. Hsia,Satyajit Sujit Kumar Mitra,Christof R. Hauck,Christof R. Hauck,Christof R. Hauck,Daniel N. Streblow,Jay A. Nelson,Dusko Ilic,Shuang Huang,Erguang Li,Glen R. Nemerow,Jay Leng,Kathryn S. R. Spencer,David A. Cheresh,David D. Schlaepfer +14 more
TL;DR: It is shown that viral Src transformation of FAK−/− cells promotes integrin-stimulated motility equal to stable FAK reexpression, and a dual role for FAK in promoting cell motility and invasion through the activation of distinct signaling pathways.
Journal ArticleDOI
Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis
Dusko Ilic,Eduardo A. C. Almeida,David D. Schlaepfer,Paul Dazin,Shinichi Aizawa,Caroline H. Damsky +5 more
TL;DR: It is reported that survival signals from fibronectin are transduced by the focal adhesion kinase (FAK) in anchorage- dependent cells, and this is the first report that p53 monitors survival signal from ECM/FAK in anch Anchorage-dependent cells.