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Stanley H. Appel
Researcher at Houston Methodist Hospital
Publications - 451
Citations - 33577
Stanley H. Appel is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Acetylcholine receptor. The author has an hindex of 97, co-authored 443 publications receiving 31282 citations. Previous affiliations of Stanley H. Appel include University of Pennsylvania & Baylor University.
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Journal ArticleDOI
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Elizabeth T. Cirulli,Brittany N. Lasseigne,Slavé Petrovski,Peter C. Sapp,Patrick A. Dion,Claire S. Leblond,Julien Couthouis,Yi-Fan Lu,Quanli Wang,Brian J. Krueger,Zhong-fa Ren,Jonathan E. M. Keebler,Yujun Han,Shawn Levy,Braden E. Boone,Jack R. Wimbish,Lindsay L. Waite,Angela Jones,John P. Carulli,Aaron G. Day-Williams,John F. Staropoli,Winnie Xin,Alessandra Chesi,Alya R. Raphael,Diane McKenna-Yasek,Janet Cady,J. M. B. Vianney de Jong,Kevin P. Kenna,Bradley N. Smith,Simon Topp,Jack W. Miller,Athina-Soragia Gkazi,Ammar Al-Chalabi,Leonard H. van den Berg,Jan H. Veldink,Vincenzo Silani,Nicola Ticozzi,Christopher Shaw,Robert H. Baloh,Stanley H. Appel,Ericka Simpson,Clotilde Lagier-Tourenne,Stefan M. Pulst,Summer Gibson,John Q. Trojanowski,Lauren Elman,Leo McCluskey,Murray Grossman,Neil A. Shneider,Wendy K. Chung,John Ravits,Jonathan D. Glass,Katherine B. Sims,Vivianna M. Van Deerlin,Tom Maniatis,Sebastian D. Hayes,Alban Ordureau,Sharan Swarup,John Landers,Frank Baas,Andrew S. Allen,Richard Bedlack,J. Wade Harper,Aaron D. Gitler,Guy A. Rouleau,Robert H. Brown,Matthew B. Harms,Gregory M. Cooper,Tim Harris,Richard M. Myers,David Goldstein +70 more
TL;DR: A moderate-scale sequencing study aimed at increasing the number of genes known to contribute to predisposition for ALS found several known ALS genes were found to be associated, and TBK1 (the gene encoding TANK-binding kinase 1) was identified as an ALS gene.
Journal ArticleDOI
Prevalence and patterns of cognitive impairment in sporadic ALS.
G. M. Ringholz,Stanley H. Appel,Major R. Bradshaw,Norma Cooke,Diane M. Mosnik,Diane M. Mosnik,Paul E. Schulz,Paul E. Schulz +7 more
TL;DR: These data confirm the presence of cognitive impairment in 50% of patients with ALS and particularly implicate executive dysfunction and mild memory decline in the disease process and have features consistent with FTD.
Journal ArticleDOI
A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism, and Alzheimer disease
TL;DR: It is presented that each of these disorders is due to lack of a disorder‐specific neurotrophic hormone, and central nervous system tissue culture provides a convenient system in which to assay these neurotrophic hormones and should permit a test of the hypothesis.
Journal ArticleDOI
Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction.
TL;DR: In this paper, a Cox proportional hazards model was used to predict survival time in ALS patients, which proved highly accurate for the 80% of patients at intermediate risk, and a second model was developed which accurately predicted, after an initial period of observation, the time over which ALS patients will decline a set number of points in total ALS score.
Journal ArticleDOI
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
David R. Beers,Jenny S. Henkel,Qin Xiao,Qin Xiao,Weihua Zhao,Jinghong Wang,Albert A. Yen,László Siklós,Scott R. McKercher,Stanley H. Appel +9 more
TL;DR: It is demonstrated that the expression of mSOD1G93A results in activated and neurotoxic microglia, and suggested that the lack of m SOD1 G93A expression inmicroglia may contribute to motoneuron protection, and confirmed the importance of microglio as a double-edged sword.