D
Douglas Halverson
Researcher at National Institutes of Health
Publications - 6
Citations - 785
Douglas Halverson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Metastasis suppressor & Metastasis Suppressor Gene. The author has an hindex of 6, co-authored 6 publications receiving 751 citations.
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Journal ArticleDOI
Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain.
Diane Palmieri,Julie L. Bronder,Jeanne M. Herring,Toshiyuki Yoneda,Robert J. Weil,Andreas M. Stark,Raffael Kurek,Raffael Kurek,Eleazar Vega-Valle,Lionel Feigenbaum,Douglas Halverson,Alexander O. Vortmeyer,Seth M. Steinberg,Kenneth Aldape,Patricia S. Steeg +14 more
TL;DR: Her-2 expression trends from resected human brain metastases and data from an experimental brain metastasis assay are presented, indicating that Her-2 overexpression increases the outgrowth of metastatic tumor cells in the brain in this model system.
Journal ArticleDOI
Metastasis suppressor genes: basic biology and potential clinical use.
TL;DR: It is hypothesized that elevation of metastasis suppressor gene expression in micrometastatic tumor cells in the adjuvant high-risk population of patients with breast cancer will halt metastatic colonization and have a clinical benefit.
Journal ArticleDOI
Medroxyprogesterone Acetate Elevation of Nm23-H1 Metastasis Suppressor Expression in Hormone Receptor–Negative Breast Cancer
Diane Palmieri,Douglas Halverson,Taoufik Ouatas,Christine E. Horak,Massimiliano Salerno,Jennifer Johnson,W. Douglas Figg,Melinda G. Hollingshead,Stephen D. Hursting,David Berrigan,Seth M. Steinberg,Maria J. Merino,Patricia S. Steeg +12 more
TL;DR: The preclinical results show that MPA appears to elevate Nm23-H1 metastasis suppressor gene expression, thereby reducing metastatic colonization and suggesting a new use for an old agent in a molecularly defined subset of breast cancer patients.
Journal Article
Dexamethasone and medroxyprogesterone acetate elevate Nm23-H1 metastasis suppressor gene expression in metastatic human breast carcinoma cells: new uses for old compounds.
TL;DR: MPA represents a first generation lead agent for the elevation of Nm23-H1 metastasis suppressor expression and the inhibition of metastatic colonization.
Journal ArticleDOI
Nm23-H1 Metastasis Suppressor Expression Level Influences the Binding Properties, Stability, and Function of the Kinase Suppressor of Ras1 (KSR1) Erk Scaffold in Breast Carcinoma Cells
TL;DR: It is hypothesized that altered expression levels of Nm23-H1 influence the binding properties, stability, and function of the KSR1 scaffold, which is modulated by metastasis suppressor expression.