L
Lionel Feigenbaum
Researcher at Science Applications International Corporation
Publications - 79
Citations - 11407
Lionel Feigenbaum is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: T cell & CD8. The author has an hindex of 51, co-authored 79 publications receiving 10598 citations. Previous affiliations of Lionel Feigenbaum include Medical University of Vienna & Johns Hopkins University.
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Journal ArticleDOI
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells
Willem W. Overwijk,Marc R. Theoret,Steven E. Finkelstein,Deborah R. Surman,Laurina A. de Jong,Florry A. Vyth-Dreese,Trees A. M. Dellemijn,Paul A. Antony,Paul J. Spiess,Douglas C. Palmer,David M. Heimann,Christopher A. Klebanoff,Zhiya Yu,Leroy N. Hwang,Lionel Feigenbaum,Ada M. Kruisbeek,Steven A. Rosenberg,Nicholas P. Restifo +17 more
TL;DR: It is found that tumor growth and lethality were unchanged in mice even after adoptive transfer of large numbers of T cells specific for an MHC class I–restricted epitope of the self/tumor antigen gp100, illustrating that adoptive transferof T cells and IL-2 can augment the function of a cancer vaccine.
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Life without white fat: a transgenic mouse
Jaideep Moitra,Mark M. Mason,Michelle Olive,Dmitry Krylov,Oksana Gavrilova,Bernice Marcus-Samuels,Lionel Feigenbaum,Eric Lee,Toshifumi Aoyama,Michael Eckhaus,Marc L. Reitman,Charles Vinson +11 more
TL;DR: The A-ZIP/F-1 phenotype suggests a mouse model for the human disease lipoatrophic diabetes (Seip-Berardinelli syndrome), indicating that the lack of fat can cause diabetes.
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Tumor-specific Th17-polarized cells eradicate large established melanoma
Pawel Muranski,Andrea Boni,Paul A. Antony,Lydie Cassard,Kari R. Irvine,Andrew Kaiser,Chrystal M. Paulos,Douglas C. Palmer,Christopher E. Touloukian,Krzysztof Ptak,Luca Gattinoni,Claudia Wrzesinski,Christian S. Hinrichs,Keith W. Kerstann,Lionel Feigenbaum,Chi-Chao Chan,Nicholas P. Restifo +16 more
TL;DR: Data indicate that the appropriate in vitro polarization of effector CD4+ T cells is decisive for successful tumor eradication, and this principle should be considered in designing clinical trials involving adoptive transfer-based immunotherapy of human malignancies.
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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.
TL;DR: Molecular mapping of CD28 costimulation showed that Treg cell generation requires a motif that binds the tyrosine kinase Lck, precisely the same motif that is required for CD28costimulation of interleukin 2 production.
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Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation
Jonathan A. Deane,Prapaporn Pisitkun,Rebecca S. Barrett,Lionel Feigenbaum,Terrence Town,Jerrold M. Ward,Richard A. Flavell,Silvia Bolland +7 more
TL;DR: It is demonstrated that duplication of the Tlr7 gene was the sole requirement for this accelerated autoimmunity, because reduction of TLR7 gene dosage abolished the Yaa phenotype.