Douglas J. Begg

TL;DR: It is suggested that PknG may contribute to the pathogenesis of MAP by phosphorylating macrophage signalling and/or adaptor molecules as observed with other pathogenic mycobacterial species.

TL;DR: The immune response in sheep to Mycobacterium avium subspecies paratuberculosis infections is examined, specifically the antigen-specific interferon gamma (IFN-γ) and antibody responses as surrogates of T helper-1 and Th2 immunity.

TL;DR: A critical literature review of experimental infection models for Johne's disease in farm and laboratory animals was conducted and it was generally agreed that the faecal-oral route is the most important natural route of exposure and the oral route is therefore the preferred route of experimental inoculation to achieve Johne' disease that closely resembles natural infection.

TL;DR: A new test, the high-throughput-Johnes (HT-J), to detect M. paratuberculosis in feces is described and validation data meet the consensus-based reporting standards for diagnostic test accuracy studies for paratubculosis and the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines.

TL;DR: Are the common mycobacterial infections of humans and animals useful "models" for each other, or are the differences between them too great to enable meaningful extrapolation?