M
Melissa Richard-Greenblatt
Researcher at University Health Network
Publications - 42
Citations - 713
Melissa Richard-Greenblatt is an academic researcher from University Health Network. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 18 publications receiving 481 citations. Previous affiliations of Melissa Richard-Greenblatt include University of British Columbia & McMaster University.
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Journal ArticleDOI
Protein Kinase G Induces an Immune Response in Cows Exposed to Mycobacterium avium Subsp. paratuberculosis .
Horacio Bach,Melissa Richard-Greenblatt,Eviatar Bach,M. Chaffer,Wanika Lai,Greg Keefe,Douglas J. Begg +6 more
TL;DR: It is suggested that PknG may contribute to the pathogenesis of MAP by phosphorylating macrophage signalling and/or adaptor molecules as observed with other pathogenic mycobacterial species.
Journal ArticleDOI
Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis
Vikram Saini,Bridgette M. Cumming,Loni Guidry,Dirk A. Lamprecht,John H. Adamson,Vineel P. Reddy,Krishna C. Chinta,James H. Mazorodze,Joel N. Glasgow,Melissa Richard-Greenblatt,Anaximandro Gómez-Velasco,Horacio Bach,Yossef Av-Gay,Hyungjin Eoh,Kyu Y. Rhee,Adrie J. C. Steyn +15 more
TL;DR: It is reported that Mtb WhiB3, a 4Fe-4S redox sensor protein, regulates EGT production and maintains bioenergetic homeostasis and that EGT modulates drug sensitivity.
Journal ArticleDOI
Endothelial Activation: The Ang/Tie Axis in Sepsis.
Aleksandra Leligdowicz,Melissa Richard-Greenblatt,Julie Wright,Valerie M. Crowley,Kevin C. Kain +4 more
TL;DR: How the Ang/Tie2 pathway is implicated in sepsis is summarized and its prognostic as well as therapeutic utility in life-threatening infections is described.
Journal ArticleDOI
Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity
Melissa Richard-Greenblatt,Horacio Bach,John H. Adamson,Sandra Peña-Diaz,Wu Li,Adrie J. C. Steyn,Yossef Av-Gay +6 more
TL;DR: The findings together with observed elevated levels of EGT in a pknD transposon mutant during in vitro growth suggests that EgtD phosphorylation by PknD negatively regulates EGT biosynthesis.
Posted ContentDOI
Does a humoral correlate of protection exist for SARS-CoV-2? A systematic review
Julie Perry,Selma Osman,James Wright,Melissa Richard-Greenblatt,Sarah A Buchan,Manish Sadarangani,Shelly Bolotin +6 more
TL;DR: The reviewed literature was limited by a wide variation in assay methodology and antibody targets, and suggest that if it exists, a SARS-CoV-2 CoP is likely relative, where higher antibody levels decrease the risk of infection, but do not eliminate it completely.