D
Douglas R. Houston
Researcher at University of Edinburgh
Publications - 50
Citations - 2158
Douglas R. Houston is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Chitinase & Virtual screening. The author has an hindex of 23, co-authored 46 publications receiving 1873 citations. Previous affiliations of Douglas R. Houston include University of Dundee & McGill University.
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Journal ArticleDOI
The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate.
Douglas R. Houston,Ian M. Eggleston,Bjørnar Synstad,Vincent G. H. Eijsink,Daan M. F. van Aalten +4 more
TL;DR: The structure reveals that the cyclic dipeptide inhibits chitinases by structurally mimicking a reaction intermediate, and could, on the basis of its accessible chemistry, be a candidate for further optimization.
Journal ArticleDOI
Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance
Ewan M. McNeil,Katy R. Astell,Ann Marie Ritchie,Steven Shave,Douglas R. Houston,Preeti Bakrania,Hayley M. Jones,Puneet Khurana,Claire Wallace,Tim Chapman,Martin A. Wear,Malcolm D. Walkinshaw,Barbara Saxty,David W. Melton,David W. Melton +14 more
TL;DR: It is demonstrated that two of these compounds display specificity in vitro for ERCC1-XPF over two other endonucleases, bind to ER CC1- XPF, inhibit Nucleotide Excision Repair in two independent assays and specifically sensitise Nucleosphate Excision repair-proficient human and mouse cells to cisplatin.
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Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking.
Gisela Henriques,Gisela Henriques,Axel Martinelli,Axel Martinelli,Axel Martinelli,Louise A. Rodrigues,Katarzyna Modrzynska,Katarzyna Modrzynska,Richard Fawcett,Douglas R. Houston,Sofia T. Borges,Umberto D'Alessandro,Halidou Tinto,Corine Karema,Paul Hunt,Pedro Cravo,Pedro Cravo +16 more
TL;DR: An increased artemisinin-resistant phenotype occurs along with a mutation in a functional element of the AP2 adaptor protein complex, which suggests that endocytosis and trafficking of membrane proteins may be involved, generating new insights into possible mechanisms of resistance.
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Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy
Leo J. Dudley,Ainara G. Cabodevilla,Agata N. Makar,Martin Sztacho,Tim Michelberger,Joseph A. Marsh,Douglas R. Houston,Sascha Martens,Xuejun Jiang,Noor Gammoh +9 more
TL;DR: The findings indicate that ATG16L1 harbours an intrinsic ability to bind lipids that plays an essential role during LC3 lipidation and autophagosome maturation.
Journal ArticleDOI
Interactions of a Family 18 Chitinase with the Designed Inhibitor HM508 and Its Degradation Product, Chitobiono-δ-lactone
Gustav Vaaje-Kolstad,Andrea Vasella,Martin G. Peter,Catharina Netter,Douglas R. Houston,Bjørge Westereng,Bjørnar Synstad,Vincent G. H. Eijsink,Daan M. F. van Aalten +8 more
TL;DR: Analysis of the interaction between the family 18 chitinase ChiB from Serratia marcescens and the designed inhibitor N,N′-diacetylchitobionoxime-N-phenylcarbamate reveals that the active site preferentially binds the 4E conformation of the -1 sugar, which resembles the proposed transition state of the reaction.