抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

http://www.mtdna.or.kr/neowiz/board/up_files/files_17/Chitin_Chitosan_polymers_chemistrySolubilityFiberFormation.pdf

Chitin and chitosan polymers: Chemistry, solubility and fiber formation

Chitosan-based hydrogels for controlled, localized drug delivery

This review describes the most common methods for recovery of chitin from marine organisms. In depth, both enzymatic and chemical treatments for the step of deproteinization are compared, as well as different conditions for demineralization. The conditions of chitosan preparation are also discussed, since they significantly impact the synthesis of chitosan with varying degree of acetylation (DA) and molecular weight (MW). In addition, the main characterization techniques applied for chitin and chitosan are recalled, pointing out the role of their solubility in relation with the chemical structure (mainly the acetyl group distribution along the backbone). Biological activities are also presented, such as: antibacterial, antifungal, antitumor and antioxidant. Interestingly, the relationship between chemical structure and biological activity is demonstrated for chitosan molecules with different DA and MW and homogeneous distribution of acetyl groups for the first time. In the end, several selected pharmaceutical and biomedical applications are presented, in which chitin and chitosan are recognized as new biomaterials taking advantage of their biocompatibility and biodegradability.

/pdf/chitin-and-chitosan-preparation-from-marine-sources-395brtgt7i.pdf

Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications

Chem. Pharm. Bull.(オピニオン)

Size-controlled hydroxyapatite nanoparticles as self-organized organic-inorganic composite materials

Many quinones and their precursors, which are transformed oxidatively into quinones and/or quinone methides, are important natural products. As secondary metabolites, they frequently possess antibiotic and cytotoxic activities, in addition to acting sometimes as pathogens. Several plants and animals, especially insects, use quinonoid substances for defense, often with spectacular results. On the macromolecular level, quinone methides have a key role in the plant kingdom in lignin biosynthesis; the biosynthesis of melanoproteins exemplifies the reactions of o-quinones in the animal kingdom. In insects, cross-linking of structural proteins through quinones and quinone methides results in the construction of the sclerotized exoskeleton. For mankind, the reactivity of quinones in biological systems has far-reaching consequences of pharmaceutical, toxicological, and technical relevance. The examples in this review show that a common principle underlies these reactions, namely, the chemical modification of biopolymers. As demonstrated particularly well in a more detailed discussion of the chemical principles of insect cuticle sclerotization, several major and important new results have emerged from the development and applications of modern methods of sample separation and from solid-state NMR spectroscopy.

Chemical Modifications of Biopolymers by Quinones and Quinone Methides

The insect cuticle is an extracellular structure covering the total outer surface of the animal and providing protection against harmful influences from the environment. The mechanical properties of cuticles may vary considerably, and pronounced regional differences are generally observed. The properties may also change during development, and it can be assumed that the physical and chemical properties of all cuticular regions tend to be close to the optimal for proper physiological function during all developmental stages. Cuticular regions can be stabilized by the process of sclerotization, whereby o-diphenols are oxidatively incorporated into the material. Our current knowledge of the sclerotization process is reviewed, and it is suggested that the main features of the chemistry of sclerotization probably have been established, and that the major questions now remaining concern the precise regional and temporal control of the process.

Martin G. Peter

Papers

Size-controlled hydroxyapatite nanoparticles as self-organized organic-inorganic composite materials

Chemical Modifications of Biopolymers by Quinones and Quinone Methides

Cuticular sclerotization in insects

Physico-chemical characterization of chitosans varying in degree of acetylation

Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica