Dror Baran

TL;DR: The findings uncover a dichotomous molecular function for the reprogramming factors, serving to reactivate endogenous pluripotency networks while simultaneously directly recruiting the Mbd3/NuRD repressor complex that potently restrains the reactivation of OSKM downstream target genes.

TL;DR: An algorithm is developed that uses information on backbone conformations and sequence-conservation patterns observed in natural antibodies to design new antibody binders, which were as stable as natural antibodies, despite having >30 mutations from mammalian antibody germlines.

TL;DR: A combinatorial backbone and sequence optimization algorithm called AbDesign is described, which leverages the large number of sequences and experimentally determined molecular structures of antibodies to construct new antibody models, dock them against target surfaces and optimize their sequence and backbone conformation for high stability and binding affinity.

TL;DR: New functional motifs in the Msn2 transcriptional-activating domain (TAD) are identified and it is shown that one of these motifs is functionally conserved in several yeast species, highlighting a common mechanism of Msn1 transcriptional activation throughout yeast evolution.

TL;DR: It is found that MamA has remained remarkably constant throughout evolution with minimal change between different taxa despite sequence variations, indicating that magnetotaxis likely did not spread via horizontal gene transfer and instead has a significantly earlier, primordial origin.