J
Jacob H. Hanna
Researcher at Weizmann Institute of Science
Publications - 149
Citations - 34071
Jacob H. Hanna is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 57, co-authored 137 publications receiving 30181 citations. Previous affiliations of Jacob H. Hanna include Hebrew University of Jerusalem & Massachusetts Institute of Technology.
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Journal ArticleDOI
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Menno P. Creyghton,Albert W. Cheng,G. Grant Welstead,Tristan Kooistra,Bryce W. Carey,Eveline J. Steine,Jacob H. Hanna,Michael A. Lodato,Garrett M. Frampton,Phillip A. Sharp,Laurie A. Boyer,Richard A. Young,Rudolf Jaenisch +12 more
TL;DR: The epigenetic landscape of enhancer elements in embryonic stem cells and several adult tissues in the mouse is interrogated and it is found that histone H3K27ac distinguishes active enhancers from inactive/poised enhancers and poised enhancer networks provide clues to unrealized developmental programs.
Journal ArticleDOI
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Alexander Meissner,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Hongcang Gu,Marius Wernig,Jacob H. Hanna,Andrey Sivachenko,Xiaolan Zhang,Bradley E. Bernstein,Bradley E. Bernstein,Chad Nusbaum,David B. Jaffe,Andreas Gnirke,Rudolf Jaenisch,Eric S. Lander +14 more
TL;DR: Low-throughput reduced representation bisulphite sequencing is established as a powerful technology for epigenetic profiling of cell populations relevant to developmental biology, cancer and regenerative medicine.
Journal ArticleDOI
Epigenetic memory in induced pluripotent stem cells
Kibem Kim,Akiko Doi,Bo Wen,K. Ng,Rui Zhao,Patrick Cahan,Jonghwan Kim,Martin J. Aryee,Hong Ji,Lauren I.R. Ehrlich,Lauren I.R. Ehrlich,A. Yabuuchi,A. Takeuchi,K. C. Cunniff,H. Hongguang,Shannon McKinney-Freeman,Olaia Naveiras,T. J. Yoon,T. J. Yoon,Rafael A. Irizarry,Namyoung Jung,Jun Seita,Jacob H. Hanna,Peter Murakami,Rudolf Jaenisch,Ralph Weissleder,Stuart H. Orkin,Irving L. Weissman,Andrew P. Feinberg,George Q. Daley +29 more
TL;DR: It is observed that low-passage induced pluripotent stem cells (iPSCs) derived by factor-based reprogramming of adult murine tissues harbour residual DNA methylation signatures characteristic of their somatic tissue of origin, which favours their differentiation along lineages related to the donor cell, while restricting alternative cell fates.
Epigenetic memory in induced pluripotent stem cells
Kibem Kim,Akiko Doi,Bo Wen,K. Ng,Rui Zhao,Patrick Cahan,Jonghwan Kim,Martin J. Aryee,Hong Ji,Lauren I.R. Ehrlich,Lauren I.R. Ehrlich,A. Yabuuchi,A. Takeuchi,K. C. Cunniff,H. Hongguang,Shannon McKinney-Freeman,Olaia Naveiras,T. J. Yoon,T. J. Yoon,Rafael A. Irizarry,Namyoung Jung,Jun Seita,Jacob H. Hanna,Peter Murakami,Rudolf Jaenisch,Ralph Weissleder,Stuart H. Orkin,Irving L. Weissman,Andrew P. Feinberg,George Q. Daley +29 more
TL;DR: The authors showed that low-passage induced pluripotent stem cells (iPSCs) derived by factor-based reprogramming of adult murine tissues harbor residual DNA methylation signatures characteristic of their somatic tissue of origin.
Journal ArticleDOI
Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin
Jacob H. Hanna,Marius Wernig,Marius Wernig,Styliani Markoulaki,Styliani Markoulaki,Chiao-Wang Sun,Chiao-Wang Sun,Alexander Meissner,Alexander Meissner,John P. Cassady,John P. Cassady,Caroline Beard,Caroline Beard,Tobias Brambrink,Tobias Brambrink,Li-Chen Wu,Li-Chen Wu,Tim M. Townes,Tim M. Townes,Rudolf Jaenisch,Rudolf Jaenisch +20 more
TL;DR: It is shown that mice can be rescued after transplantation with hematopoietic progenitors obtained in vitro from autologous iPS cells, providing proof of principle for using transcription factor–induced reprogramming combined with gene and cell therapy for disease treatment in mice.