Yoach Rais

TL;DR: It is shown that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition from the pluripotent to the differentiated state.

TL;DR: The novel naive pluripotent cells validated herein retain molecular characteristics and functional properties that are highly similar to mouse naive ES cells, and distinct from conventional primed human pluripotency.

TL;DR: The findings uncover a dichotomous molecular function for the reprogramming factors, serving to reactivate endogenous pluripotency networks while simultaneously directly recruiting the Mbd3/NuRD repressor complex that potently restrains the reactivation of OSKM downstream target genes.

TL;DR: It is shown in mice and humans that the histone H3 methylated Lys’27 (H3K27) demethylase Utx regulates the efficient induction, rather than maintenance, of pluripotency, and highlights the principle that molecular regulators mediating loss of repressive chromatin during in vivo germ cell reprograming can be co-opted during in vitro reprogramming towards ground state pluripOTency.

TL;DR: A special subset of human decidual natural killer cells is reported on, which “remember” pregnancy and better support subsequent pregnancies, which might explain why first pregnancies are at increased risk of developing diseases of poor placentation.