D
Dvir Aran
Researcher at Technion – Israel Institute of Technology
Publications - 52
Citations - 8413
Dvir Aran is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 20, co-authored 43 publications receiving 4084 citations. Previous affiliations of Dvir Aran include University of California, Berkeley & University of California, San Francisco.
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Journal ArticleDOI
xCell: digitally portraying the tissue cellular heterogeneity landscape
TL;DR: This work presents xCell, a novel gene signature-based method, and uses it to infer 64 immune and stromal cell types and shows that xCell outperforms other methods.
Journal ArticleDOI
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
Dvir Aran,Agnieszka P. Looney,Leqian Liu,Esther Wu,Valerie Fong,Austin Hsu,Suzanna Chak,Ram P. Naikawadi,Paul J. Wolters,Adam R. Abate,Adam R. Abate,Atul J. Butte,Mallar Bhattacharya +12 more
TL;DR: Using scRNA-seq analysis, Bhattacharya and colleagues identify a subset of profibrotic lung macrophages that have a gene expression signature intermediate between those of monocytes and alveolar macrophage.
Posted ContentDOI
xCell: Digitally portraying the tissue cellular heterogeneity landscape
TL;DR: XCell as mentioned in this paper is a gene-signature based method for inferring 64 immune and stroma cell types from 1,822 transcriptomic profiles of pure human cells from various sources, employed a curve fitting approach for linear comparison of cell types, and introduced a novel spillover compensation technique for separating closely related cell types.
Journal ArticleDOI
Systematic pan-cancer analysis of tumour purity
TL;DR: A systematic analysis using different measurement modalities of tumour purity in >10,000 samples across 21 cancer types from the Cancer Genome Atlas finds an immunotherapy gene signature in several cancer types that is not detected by traditional differential expression analyses.
Journal ArticleDOI
Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer.
David Y. Oh,Serena S. Kwek,Siddharth S. Raju,Tony Li,Elizabeth E. McCarthy,Eric D. Chow,Dvir Aran,Arielle Ilano,Chien-Chun Steven Pai,Chiara Rancan,Kathryn Allaire,Arun Burra,Yang Sun,Matthew H. Spitzer,Serghei Mangul,Sima P. Porten,Maxwell V. Meng,Terence W. Friedlander,Chun Jimmie Ye,Lawrence Fong +19 more
TL;DR: A gene signature of cytotoxic CD4+ T cells in tumors predicts a clinical response in 244 metastatic bladder cancer patients treated with anti-PD-L1, and several tumor-specific states are found, including multiple distinct states of regulatory T cells.