E.I.H. van der Voort

TL;DR: In this paper, it was shown that signalling through CD40 can replace CD4+ T-helper cells in priming of helper-dependent CD8+ CTL responses.

TL;DR: Modification of the Ad5E1 peptide vaccine fails to convert immunosuppression into effective antitumor vaccination and the Ad 5E1-derived peptides evoke a strong tumor-protective CTL response when presented on dendritic cells (DC), indicating that the in vivo CTL-tolerizing potential of these peptides is converted to specific immunostimulation.

TL;DR: This work has raised CTL, using responding T lymphocytes from healthy donor blood, that lysed not only cells incubated with an HLA-A*0201-binding tyrosinase peptide but also melanoma cells endogenously processing and presenting the epitope.

TL;DR: Observations indicate that T cell help for cytotoxic T lymphocytes is mediated by CD40-CD40Ligand (L) interactions, most likely through activation of professional antigen-presenting cells that cross-present cellular antigens to these T cells.

TL;DR: Results show an immunological response of immune cells from ACPA+ RA patients in a citrulline-specific manner, and indicate a role for IgE-ACPAs and FcεRI-positive cells in the pathogenesis of RA.