A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.

Compounds and methods for the treatment or prevention of flavivirus infections

Factors and Mechanisms that Influence the Reactivity of Trivalent Copper: A Novel Oxidant for Selective Degradation of Antibiotics

Cp* Iridium Precatalysts for Selective C- H Oxidation with Sodium Periodate As the Terminal Oxidant

Iron-Catalyzed Generation of α-Amino Nitriles from Tertiary Amines

Thermodynamic measurements were made for the binary mixture of water + γ-valerolactone (GVL) and for pure GVL to facilitate the development of the technology of lignin removal from lignocellulosic biomass (Fang, W.; Sixta, H. Advanced Biorefinery based on the Fractionation of Biomass in γ - Valerolactone and Water. ChemSusChem 2015, 8, 73−76). The density and vapor pressure of pure GVL as a function of temperature were measured and correlated for a wide range of the temperatures and pressures. Isothermal vapor–liquid equilibrium (VLE) data of the binary mixture of water + GVL were measured at 350.2 K with a static total pressure apparatus. Absence of an azeotrope was confirmed by circulation still measurements with diluted GVL solutions. Excess molar enthalpy (hE) of the mixture for the whole range of mole fractions including infinite dilution was measured using a SETARAM C80 calorimeter equipped with a flow mixing cell at 322.6 and 303.2 K. The VLE and hE data were used for the optimization of UNIQUAC an...

Vapor–Liquid Equilibria, Excess Enthalpy, and Density of Aqueous γ-Valerolactone Solutions.

The conversion of amines into 2,2-dichloroaldehydes (III) and chloroalkanes (V) are new reactions of oxidative substitution of the amino group in primary aliphatic amines. The reaction mechanism evidently includes a one-electron oxidation of (Ia-c) to aminyl radicals RCH=CH=NH on deprotonation of which aldimines RCH2CH=NH are obtained. The latter are oxidized into nitriles (IIa-c) and are also hydrolyzed to aldehydes RCH=CHO (Via-c) which are oxidized to acids (IVa-c). It is possible that under the reaction conditions (Via-c) interact with the initial (Ia-c) with the formation of Schiff bases RCH2CH=NCH2CH2R (VIIa-c). On oxidative chlorination and hydrolysis these form (IIIa-c). The proposed mechanism was confirmed by control experiments on the oxidation of C3HTCH2CH=NCH2CH=CaH9 (VIId) to a mixture of (IIIa) (14%) and (Ib) (48%). Similarly (IIIa) was obtained from a mixture of (Ib) and (Via) in 13% yield from (Via) at a conversion of (Ib) of 34%. It should be recorded that only (IVa) was obtained from (Via) under the action of the system Na=S~Os--CuCI2 and oxidative chlorination with the formation of (IIIa) did not occur.

E. I. Troyanskii

Papers

Oxidative substitution of the amino group in primary aliphatic amines