E
E.J. Slootweg
Researcher at Wageningen University and Research Centre
Publications - 30
Citations - 897
E.J. Slootweg is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Effector & Potato virus X. The author has an hindex of 11, co-authored 27 publications receiving 779 citations.
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Journal ArticleDOI
Nucleocytoplasmic Distribution Is Required for Activation of Resistance by the Potato NB-LRR Receptor Rx1 and Is Balanced by Its Functional Domains
E.J. Slootweg,Jan Roosien,Laurentiu N. Spiridon,Andrei-Jose Petrescu,Wladimir I. L. Tameling,Matthieu H. A. J. Joosten,Rikus Pomp,Casper van Schaik,R.H.L. Dees,Jan Willem Borst,Geert Smant,Arjen Schots,Jaap Bakker,Aska Goverse +13 more
TL;DR: It is demonstrated that Rx1, which confers extreme resistance to Potato virus X, is located both in the nucleus and cytoplasm, and this results support a model in which interdomain interactions and folding states determine the nucleocy toplasmic distribution of Rx1.
Journal ArticleDOI
RanGAP2 Mediates Nucleocytoplasmic Partitioning of the NB-LRR Immune Receptor Rx in the Solanaceae, Thereby Dictating Rx Function
Wladimir I. L. Tameling,Claudia Nooijen,Nora R. Ludwig,Marta Boter,E.J. Slootweg,Aska Goverse,Ken Shirasu,Matthieu H. A. J. Joosten +7 more
TL;DR: The data show that a balanced nucleocytoplasmic partitioning of Rx is required for proper regulation of defense signaling and indicate that RanGAP2 regulates this partitioning by serving as a cytop lasmic retention factor for Rx.
Journal ArticleDOI
Stepwise artificial evolution of a plant disease resistance gene
TL;DR: It is concluded that artificial evolution of NB-LRR disease resistance genes in crops can be enhanced by modification of both activation and recognition phases, to both accentuate the positive and eliminate the negative aspects of disease resistance.
Journal ArticleDOI
The Effector SPRYSEC-19 of Globodera rostochiensis Suppresses CC-NB-LRR-Mediated Disease Resistance in Plants
W.J. Postma,E.J. Slootweg,Sajid Ur Rehman,A.M. Finkers-Tomczak,Tom O.G. Tytgat,Kasper van Gelderen,Jose L. Lozano-Torres,Jan Roosien,Rikus Pomp,Casper van Schaik,Jaap Bakker,Aska Goverse,Geert Smant +12 more
TL;DR: It is demonstrated that potato cyst nematodes secrete effectors that enable the suppression of programmed cell death and disease resistance mediated by several CC-NB-LRR proteins in plants.
Journal ArticleDOI
Structural determinants at the interface of the ARC2 and leucine-rich repeat domains control the activation of the plant immune receptors Rx1 and Gpa2.
E.J. Slootweg,Laurentiu N. Spiridon,Jan Roosien,P.B.E. Butterbach,Rikus Pomp,Lotte B. Westerhof,Ruud H. P. Wilbers,Erin Bakker,Jaap Bakker,Andrei-Jose Petrescu,Geert Smant,Aska Goverse +11 more
TL;DR: Structural determinants governing the interaction between the NB-ARC and LRR in the highly homologous plant immune receptors Gpa2 and Rx1, which recognize the potato cyst nematode Globodera pallida and Potato virus X are reported.