E
E.L. Baxter
Researcher at Stanford University
Publications - 20
Citations - 607
E.L. Baxter is an academic researcher from Stanford University. The author has contributed to research in topics: Cypa & Active site. The author has an hindex of 9, co-authored 20 publications receiving 512 citations. Previous affiliations of E.L. Baxter include SLAC National Accelerator Laboratory & University of California, San Diego.
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Journal ArticleDOI
Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography
Daniel A. Keedy,Lillian R. Kenner,Matthew Warkentin,Rahel A. Woldeyes,Jesse B. Hopkins,Michael C. Thompson,Aaron S. Brewster,Andrew H. Van Benschoten,E.L. Baxter,Monarin Uervirojnangkoorn,Monarin Uervirojnangkoorn,Scott E McPhillips,J. Song,Roberto Alonso-Mori,James M. Holton,James M. Holton,James M. Holton,William I. Weis,William I. Weis,Axel T. Brunger,S. Michael Soltis,Henrik T. Lemke,Ana Gonzalez,Nicholas K. Sauter,Aina E. Cohen,Henry van den Bedem,Robert E. Thorne,James S. Fraser +27 more
TL;DR: The diffraction-before-destruction nature of XFEL experiments provides a radiation-damage-free view of the functionally important alternative conformations of CypA, confirming earlier synchrotron-based results and motivating a new generation of temperature- and time-resolved experiments to structurally characterize the dynamic underpinnings of protein function.
Journal ArticleDOI
Goniometer-based femtosecond crystallography with X-ray free electron lasers
Aina E. Cohen,S. Michael Soltis,Ana Gonzalez,Laura Aguila,Roberto Alonso-Mori,Christopher O. Barnes,E.L. Baxter,Winnie Brehmer,Aaron S. Brewster,Axel T. Brunger,Guillermo Calero,Joseph F. Chang,Matthieu Chollet,Paul Ehrensberger,Thomas Eriksson,Yiping Feng,Johan Hattne,Britt Hedman,Michael Hollenbeck,James M. Holton,James M. Holton,Stephen Keable,Brian K. Kobilka,Elena G. Kovaleva,Andrew C. Kruse,Henrik T. Lemke,Guowu Lin,Artem Y. Lyubimov,Aashish Manglik,Irimpan I. Mathews,S.E. McPhillips,Silke Nelson,John W. Peters,Nicholas K. Sauter,Clyde A. Smith,J. Song,Hilary P. Stevenson,Yingssu Tsai,Monarin Uervirojnangkoorn,Vladimir Vinetsky,Soichi Wakatsuki,William I. Weis,Oleg A. Zadvornyy,Oliver B. Zeldin,Diling Zhu,Keith O. Hodgson +45 more
TL;DR: Screening results from cryocooled crystals of β2-adrenoreceptor and an RNA polymerase II complex indicate the potential to extend the diffraction resolution obtainable from very radiation-sensitive samples beyond that possible with undulator-based synchrotron sources.
Journal ArticleDOI
Capture and X-ray diffraction studies of protein microcrystals in a microfluidic trap array
Artem Y. Lyubimov,Thomas D. Murray,Antoine Koehl,Ismail Emre Araci,Monarin Uervirojnangkoorn,Oliver B. Zeldin,Aina E. Cohen,S. Michael Soltis,E.L. Baxter,Aaron S. Brewster,Nicholas K. Sauter,Axel T. Brunger,James M. Berger +12 more
TL;DR: A microfluidic platform has been developed for the capture and X-ray analysis of protein microcrystals, affording a means to improve the efficiency of XFEL and synchrotron experiments.
Journal ArticleDOI
High-density grids for efficient data collection from multiple crystals
E.L. Baxter,Laura Aguila,Roberto Alonso-Mori,Christopher O. Barnes,Christopher A. Bonagura,Winnie Brehmer,Axel T. Brunger,Axel T. Brunger,Guillermo Calero,Tom T. Caradoc-Davies,Tom T. Caradoc-Davies,Ruchira Chatterjee,William F. DeGrado,James S. Fraser,Mohamed Ibrahim,Jan Kern,Jan Kern,Brian K. Kobilka,Andrew C. Kruse,Karl M. Larsson,Heinrik T. Lemke,Artem Y. Lyubimov,Artem Y. Lyubimov,Aashish Manglik,S.E. McPhillips,Erik Norgren,Siew S. Pang,S.M. Soltis,J. Song,Jessica L. Thomaston,Yingssu Tsai,William I. Weis,Rahel A. Woldeyes,Vittal K. Yachandra,Junko Yano,Athina Zouni,Aina E. Cohen +36 more
TL;DR: A high-density sample mount has been developed for efficient goniometer-based sample delivery at synchrotron and XFEL sources.
Journal ArticleDOI
Crystal structure of the pristine peroxidase ferryl center and its relevance to proton-coupled electron transfer.
Georges Chreifi,E.L. Baxter,Tzanko Doukov,Aina E. Cohen,S.E. McPhillips,J. Song,Yergalem T. Meharenna,S. Michael Soltis,Thomas L. Poulos +8 more
TL;DR: The 1.5-Å crystal structure of cytochrome c peroxidase (CCP) compound I (CmpI) using data obtained with the Stanford Linear Coherent Light Source (LCLS) is reported, indicating that a water molecule is ideally positioned to shuttle protons between an iron-linked oxygen and the active site catalytic His.