E
E Mahlow
Researcher at University of Duisburg-Essen
Publications - 2
Citations - 279
E Mahlow is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Neuroblastoma & Exome. The author has an hindex of 2, co-authored 2 publications receiving 218 citations. Previous affiliations of E Mahlow include Boston Children's Hospital.
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Journal ArticleDOI
Mutational dynamics between primary and relapse neuroblastomas
Alexander Schramm,Johannes Köster,Johannes Köster,Yassen Assenov,Kristina Althoff,Martin Peifer,E Mahlow,Andrea Odersky,Daniela Beisser,Corinna Ernst,Anton G. Henssen,Anton G. Henssen,Anton G. Henssen,Harald Stephan,Christopher Schröder,Lukas C. Heukamp,Anne Engesser,Yvonne Kahlert,Jessica Theissen,Barbara Hero,Frederik Roels,Janine Altmüller,Peter Nürnberg,Kathy Astrahantseff,Christian Gloeckner,Katleen De Preter,Christoph Plass,Sangkyun Lee,Holger N. Lode,Kai Oliver Henrich,Moritz Gartlgruber,Frank Speleman,Peter Schmezer,Frank Westermann,Sven Rahmann,Sven Rahmann,Matthias Fischer,Angelika Eggert,Angelika Eggert,Johannes H. Schulte,Johannes H. Schulte,Johannes H. Schulte +41 more
TL;DR: The mutational burden significantly increased in relapsing tumors, accompanied by altered mutational signatures and reduced subclonal heterogeneity and global allele frequencies at relapse indicated clonal mutation selection during disease progression.
Journal ArticleDOI
Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells
Kristian W. Pajtler,E Mahlow,Andrea Odersky,Sven Lindner,Harald Stephan,Ivo Bendix,Angelika Eggert,Alexander Schramm,Johannes H. Schulte +8 more
TL;DR: A model is proposed for NTRK1-mediated and NRG1-dependent attraction of adjacent SC, which in turn induce neuroblastic differentiation by secretion of the NTRk1-specific ligand, NGF, which could assist the development of new therapeutic strategies for neuroblastoma differentiation.