B
Barbara Hero
Researcher at University of Cologne
Publications - 179
Citations - 11613
Barbara Hero is an academic researcher from University of Cologne. The author has contributed to research in topics: Neuroblastoma & Cancer. The author has an hindex of 53, co-authored 168 publications receiving 9871 citations. Previous affiliations of Barbara Hero include Boston Children's Hospital.
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Journal ArticleDOI
The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report
Susan L. Cohn,Andrew D.J. Pearson,Wendy B. London,Tom Monclair,Peter F. Ambros,Garrett M. Brodeur,Andreas Faldum,Barbara Hero,Tomoko Iehara,David Machin,Véronique Mosseri,Thorsten Simon,Alberto Garaventa,Victoria Castel,Katherine K. Matthay +14 more
TL;DR: By defining homogenous pretreatment patient cohorts, the INRG classification system will greatly facilitate the comparison of risk-based clinical trials conducted in different regions of the world and the development of international collaborative studies.
Journal ArticleDOI
Telomerase activation by genomic rearrangements in high-risk neuroblastoma
Martin Peifer,Falk Hertwig,Frederik Roels,Daniel Dreidax,Moritz Gartlgruber,Roopika Menon,Andrea Krämer,Justin L. Roncaioli,Frederik Sand,Johannes M. Heuckmann,Fakhera Ikram,Rene Schmidt,Sandra Ackermann,Anne Engesser,Yvonne Kahlert,Wenzel Vogel,Janine Altmüller,Peter Nürnberg,Jean Thierry-Mieg,Danielle Thierry-Mieg,Aruljothi Mariappan,Stefanie Heynck,Erika Mariotti,Kai-Oliver Henrich,Christian Gloeckner,Graziella Bosco,Ivo Leuschner,Michal R. Schweiger,Larissa Savelyeva,Simon C. Watkins,Chunxuan Shao,Emma Bell,Thomas Höfer,Viktor Achter,Ulrich Lang,Jessica Theissen,Ruth Volland,Maral Saadati,Angelika Eggert,Bram De Wilde,Frank Berthold,Zhiyu Peng,Chen Zhao,Leming Shi,Monika Ortmann,Reinhard Büttner,Sven Perner,Barbara Hero,Alexander Schramm,Johannes H. Schulte,Johannes H. Schulte,Carl Herrmann,Carl Herrmann,Roderick J. O’Sullivan,Frank Westermann,Roman K. Thomas,Matthias G. Fischer +56 more
TL;DR: It is shown that remodelling of the genomic context abrogates transcriptional silencing of TERT in high-risk neuroblastoma and places telomerase activation in the centre of transformation in a large fraction of these tumours.
Journal ArticleDOI
Guidelines for Imaging and Staging of Neuroblastic Tumors: Consensus Report from the International Neuroblastoma Risk Group Project
Hervé Brisse,M. Beth McCarville,Claudio Granata,K. Barbara Krug,Sandra L. Wootton-Gorges,Kimio Kanegawa,Francesco Giammarile,Matthias Schmidt,Barry L. Shulkin,Katherine K. Matthay,Katherine K. Matthay,Val Lewington,Sabine Sarnacki,Barbara Hero,Michio Kaneko,Wendy B. London,Andrew D.J. Pearson,Susan L. Cohn,Tom Monclair +18 more
TL;DR: The present consensus report was written by the INRG Imaging Committee to optimize imaging and staging and reduce interobserver variability and contribute substantially to more uniform staging and thereby facilitate comparisons of clinical trials conducted in different parts of the world.
Journal ArticleDOI
Neuroblastoma screening at one year of age
Freimut H. Schilling,Claudia Spix,Frank Berthold,Rudolf Erttmann,N. Fehse,Barbara Hero,Gisela Klein,Johannes Sander,Kerstin Schwarz,Joern Treuner,Ulrich Zorn,Joerg Michaelis +11 more
TL;DR: The present findings do not support the usefulness of general screening for neuroblastoma at one year of age and reveal substantial overdiagnosis in the former group.
Journal ArticleDOI
Histone Deacetylase 8 in Neuroblastoma Tumorigenesis
Ina Oehme,Hedwig E. Deubzer,Dennis Wegener,Diana Pickert,Jan Peter Linke,Barbara Hero,Annette Kopp-Schneider,Frank Westermann,Scott M. Ulrich,Andreas von Deimling,Matthias Fischer,Olaf Witt +11 more
TL;DR: The data point toward an important role of HDAC8 in neuroblastoma pathogenesis and identify this HDAC family member as a specific drug target for the differentiation therapy of neuroblastomas.