Moritz Gartlgruber

TL;DR: It is shown that remodelling of the genomic context abrogates transcriptional silencing of TERT in high-risk neuroblastoma and places telomerase activation in the centre of transformation in a large fraction of these tumours.

TL;DR: The mutational burden significantly increased in relapsing tumors, accompanied by altered mutational signatures and reduced subclonal heterogeneity and global allele frequencies at relapse indicated clonal mutation selection during disease progression.

TL;DR: This work sequenced more than 400 pretreatment neuroblastomas and identified molecular features that characterize the three distinct clinical outcomes, and proposed a mechanistic classification of neuroblastoma that may benefit the clinical management of patients.

TL;DR: This article studied the single-cell transcriptomes of neuroblastomas and normal human developing adrenal glands at various stages of embryonic and fetal development and defined normal differentiation trajectories from Schwann cell precursors over intermediate states to neuroblasts or chromaffin cells.

TL;DR: It is found that DNA methylation patterns identify divergent patient subgroups with respect to survival and clinicobiologic variables, and intragenic enhancer methylation as a mechanism for high-risk-associated transcriptional deregulation in high- risk neuroblastomas.