C
Christopher Schröder
Researcher at University of Duisburg-Essen
Publications - 23
Citations - 563
Christopher Schröder is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 6, co-authored 17 publications receiving 387 citations.
Papers
More filters
Journal ArticleDOI
Mutational dynamics between primary and relapse neuroblastomas
Alexander Schramm,Johannes Köster,Johannes Köster,Yassen Assenov,Kristina Althoff,Martin Peifer,E Mahlow,Andrea Odersky,Daniela Beisser,Corinna Ernst,Anton G. Henssen,Anton G. Henssen,Anton G. Henssen,Harald Stephan,Christopher Schröder,Lukas C. Heukamp,Anne Engesser,Yvonne Kahlert,Jessica Theissen,Barbara Hero,Frederik Roels,Janine Altmüller,Peter Nürnberg,Kathy Astrahantseff,Christian Gloeckner,Katleen De Preter,Christoph Plass,Sangkyun Lee,Holger N. Lode,Kai Oliver Henrich,Moritz Gartlgruber,Frank Speleman,Peter Schmezer,Frank Westermann,Sven Rahmann,Sven Rahmann,Matthias Fischer,Angelika Eggert,Angelika Eggert,Johannes H. Schulte,Johannes H. Schulte,Johannes H. Schulte +41 more
TL;DR: The mutational burden significantly increased in relapsing tumors, accompanied by altered mutational signatures and reduced subclonal heterogeneity and global allele frequencies at relapse indicated clonal mutation selection during disease progression.
Journal ArticleDOI
Unstable TTTTA/TTTCA expansions in MARCH6 are associated with Familial Adult Myoclonic Epilepsy type 3
Rahel T. Florian,Florian Kraft,Elsa Leitão,Sabine Kaya,Stephan Klebe,Eloi Magnin,Anne-Fleur van Rootselaar,Julien Buratti,Theresa Kühnel,Christopher Schröder,Sebastian Giesselmann,Nikolai Tschernoster,Janine Altmueller,Anaide Lamiral,Boris Keren,Caroline Nava,Delphine Bouteiller,Sylvie Forlani,Ludmila Jornea,Regina Kubica,Tao Ye,Damien Plassard,Bernard Jost,Vincent Meyer,Jean-François Deleuze,Yannick Delpu,Mario D. M. Avarello,Lisanne S. Vijfhuizen,Gabrielle Rudolf,Edouard Hirsch,Thessa Kroes,Philipp S. Reif,Philipp S. Reif,Felix Rosenow,Felix Rosenow,Christos Ganos,Marie Vidailhet,Lionel Thivard,Alexandre Mathieu,Thomas Bourgeron,Ingo Kurth,Haloom Rafehi,Haloom Rafehi,Laura Steenpass,Bernhard Horsthemke,Eric LeGuern,Karl Martin Klein,Karl Martin Klein,Karl Martin Klein,Pierre Labauge,Mark F. Bennett,Mark F. Bennett,Melanie Bahlo,Melanie Bahlo,Jozef Gecz,Mark A. Corbett,Marina A. J. Tijssen,Arn M. J. M. van den Maagdenberg,Christel Depienne,Christel Depienne,Christel Depienne +60 more
TL;DR: Mixed intronic TTTTA/TTTCA expansions of various lengths in the first intron of MARCH6 are described as a cause of FAME3 and revealed that expansions exhibit an unexpectedly high somatic instability that can ultimately result in genomic rearrangements.
Journal ArticleDOI
Epigenetic dynamics of monocyte-to-macrophage differentiation
Stefan Wallner,Christopher Schröder,Elsa Leitão,Tea Berulava,Claudia Haak,Daniela Beißer,Sven Rahmann,Andreas S. Richter,Thomas Manke,Ulrike Bönisch,Laura Arrigoni,Sebastian Fröhler,Filippos Klironomos,Wei Chen,Nikolaus Rajewsky,Fabian Müller,Peter Ebert,Thomas Lengauer,Matthias Barann,Philip Rosenstiel,Gilles Gasparoni,Karl Nordström,Jörn Walter,Benedikt Brors,Gideon Zipprich,Bärbel Felder,Ludger Klein-Hitpass,Corinna Attenberger,Gerd Schmitz,Bernhard Horsthemke +29 more
TL;DR: A phagocytic gene network is discovered that is repressed by DNA methylation in monocytes and rapidly de-repressed after the onset of macrophage differentiation.
Journal ArticleDOI
Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function
Christopher Schröder,Elsa Leitão,Stefan Wallner,Gerd Schmitz,Ludger Klein-Hitpass,Anupam Sinha,Karl-Heinz Jöckel,Stefanie Heilmann-Heimbach,Per Hoffmann,Markus M. Nöthen,Michael Steffens,Peter Ebert,Sven Rahmann,Bernhard Horsthemke +13 more
TL;DR: Allele-specific DNA methylation occurs in discrete chromosomal regions and is driven by genetic variation in cis and trans, but in general has little effect on gene expression.
Journal ArticleDOI
A germ cell‐specific ageing pattern in otherwise healthy men
Sandra Laurentino,Jann-Frederik Cremers,Bernhard Horsthemke,Frank Tüttelmann,Karen Czeloth,Michael Zitzmann,Eva Pohl,Sven Rahmann,Christopher Schröder,Sven Berres,Klaus Redmann,Claudia Krallmann,Stefan Schlatt,Sabine Kliesch,Jörg Gromoll +14 more
TL;DR: Human male germ cells present a unique germline‐specific ageing process, which likely results in diminished fecundity in elderly men and poorer health prognosis for their offspring.