E
E. Martinotti
Researcher at University of Perugia
Publications - 25
Citations - 288
E. Martinotti is an academic researcher from University of Perugia. The author has contributed to research in topics: Alpha (ethology) & Pirenzepine. The author has an hindex of 10, co-authored 25 publications receiving 276 citations.
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Journal ArticleDOI
Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers.
Violetta Cecchetti,Vincenzo Calderone,Oriana Tabarrini,Stefano Sabatini,Enrica Filipponi,Lara Testai,Roberto Spogli,E. Martinotti,Arnaldo Fravolini +8 more
TL;DR: Compounds 4c, 5c, and 6c displayed a vasorelaxant potency at least 10 000 times greater than that of LCRK, thus becoming the most potent KCOs identified to date.
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An interdisciplinary approach to the design of new structures active at the beta-adrenergic receptor. Aliphatic oxime ether derivatives.
Bruno Macchia,Aldo Balsamo,Annalina Lapucci,Adriano Martinelli,F. Macchia,Maria Cristina Breschi,B Fantoni,E. Martinotti +7 more
TL;DR: Pharmacological in vitro tests showed that compounds examined exhibit a marked and competitive antagonism at beta-adrenoceptors; the beta 2/beta 1 selectivity ratio indicated that they are more active on the tracheal than on the cardiac beta-receptor.
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Torsadogenic cardiotoxicity of antipsychotic drugs: a structural feature, potentially involved in the interaction with cardiac HERG potassium channels.
Lara Testai,Anna Maria Paola Bianucci,Ilaria Massarelli,Maria Cristina Breschi,E. Martinotti,Vincenzo Calderone +5 more
TL;DR: A common structural feature exhibited by these drugs, despite of their remarkable chemical differences, is evidenced by a computational approach and is indicated as a possible "facilitating" requirement for their torsadogenic properties.
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Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans.
Maria Cristina Breschi,E. Martinotti,Serena Catalano,Guido Flamini,Ivano Morelli,Anna Maria Pagni +5 more
TL;DR: The traditional therapeutic indications for the use of Ajuga reptans (Labiatae) have been investigated and the H2O-soluble part of a crude and partially purified MeOH extract and two isolated iridoids, were tested for a biological activity on isolated smooth muscle preparations from guinea pig.
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Effects of subacute exposure to noise on the noradrenergic innervation of the cardiovascular system in young and aged rats: a morphofunctional study.
Antonio Paparelli,Paola Soldani,Maria Cristina Breschi,E. Martinotti,R Scatizzi,Stefano Berrettini,Antonio Pellegrini +6 more
TL;DR: The present results indicate that subacute noise stress induces both morphological and functional modifications of the noradrenergic nervous system and also that after subacUTE noise stress, morphological changes do not necessarily correspond exactly to functional data; the latter show responses that are more widely differentiated than the morphological ones.