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Roberto Spogli
Researcher at University of Perugia
Publications - 29
Citations - 237
Roberto Spogli is an academic researcher from University of Perugia. The author has contributed to research in topics: Adsorption & Chemistry. The author has an hindex of 6, co-authored 24 publications receiving 152 citations. Previous affiliations of Roberto Spogli include University of Bristol.
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Journal ArticleDOI
Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers.
Violetta Cecchetti,Vincenzo Calderone,Oriana Tabarrini,Stefano Sabatini,Enrica Filipponi,Lara Testai,Roberto Spogli,E. Martinotti,Arnaldo Fravolini +8 more
TL;DR: Compounds 4c, 5c, and 6c displayed a vasorelaxant potency at least 10 000 times greater than that of LCRK, thus becoming the most potent KCOs identified to date.
Journal ArticleDOI
Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers.
Vincenzo Calderone,Roberto Spogli,Alma Martelli,Giuseppe Manfroni,Lara Testai,Stefano Sabatini,Oriana Tabarrini,Violetta Cecchetti +7 more
TL;DR: The results of this study show that the 1, 4-benzothiazine heterocyclic nucleus is a suitable backbone for designing novel BK-openers; indeed, some of these new 1,4-benZothiazines derivatives had a vasorelaxant potency comparable or superior to that of reference Bk-activator NS-1619.
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Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability
Roberto Spogli,Maria Bastianini,Francesco Ragonese,Rossana G. Iannitti,Lorenzo Monarca,Federica Bastioli,Irina Nakashidze,Gabriele Brecchia,Laura Menchetti,Michela Codini,Cataldo Arcuri,Loretta Mancinelli,Bernard Fioretti +12 more
TL;DR: It is hypothesize that type 2 microparticles represent magnesium dihydroxide microp articles with a resveratrol shell and that they are responsible for the improved resver atrol solubility and bioavailability of Resv@MDH.
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Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide Analogues
Christopher J. Arthur,Russell J. Cox,John Crosby,Mujiber M. Rahman,Thomas J. Simpson,Florilène Soulas,Roberto Spogli,Anna E. Szafranska,James Westcott,Christopher J. Winfield +9 more
TL;DR: The acyl ACP intermediates formed during PKS catalysis could act as surrogate intermediates or starter units for PKS and may lead to the synthesis of novel compounds in vitro.
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Binding studies and GRIND/ALMOND-based 3D QSAR analysis of benzothiazine type KATP-channel openers
Emanuele Carosati,Horst Lemoine,Roberto Spogli,Dagmar Grittner,Raimund Mannhold,Oriana Tabarrini,Stefano Sabatini,Violetta Cecchetti +7 more
TL;DR: For seventeen 1,4-benzothiazine potassium channel openers, binding studies in rat aortic smooth muscle cells and cardiomyocytes were performed, their binding affinities with published relaxation data were compared, and 3D-QSAR models using GRIND/ALMOND descriptors were derived.