E. Martinotti

TL;DR: Compounds 4c, 5c, and 6c displayed a vasorelaxant potency at least 10 000 times greater than that of LCRK, thus becoming the most potent KCOs identified to date.

TL;DR: Pharmacological in vitro tests showed that compounds examined exhibit a marked and competitive antagonism at beta-adrenoceptors; the beta 2/beta 1 selectivity ratio indicated that they are more active on the tracheal than on the cardiac beta-receptor.

TL;DR: A common structural feature exhibited by these drugs, despite of their remarkable chemical differences, is evidenced by a computational approach and is indicated as a possible "facilitating" requirement for their torsadogenic properties.

TL;DR: The traditional therapeutic indications for the use of Ajuga reptans (Labiatae) have been investigated and the H2O-soluble part of a crude and partially purified MeOH extract and two isolated iridoids, were tested for a biological activity on isolated smooth muscle preparations from guinea pig.

TL;DR: The present results indicate that subacute noise stress induces both morphological and functional modifications of the noradrenergic nervous system and also that after subacUTE noise stress, morphological changes do not necessarily correspond exactly to functional data; the latter show responses that are more widely differentiated than the morphological ones.