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Eberhard Gunsilius
Researcher at Innsbruck Medical University
Publications - 162
Citations - 6364
Eberhard Gunsilius is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: Multiple myeloma & Vascular endothelial growth factor. The author has an hindex of 35, co-authored 154 publications receiving 6031 citations. Previous affiliations of Eberhard Gunsilius include University of Innsbruck & University of Ulm.
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Increase of Regulatory T Cells in the Peripheral Blood of Cancer Patients 1
Anna Maria Wolf,Dominik Wolf,Michael Steurer,G. Gastl,Eberhard Gunsilius,Beatrix Grubeck-Loebenstein +5 more
TL;DR: Evidence is provided of an increased pool of CD4(+)CD25(+) regulatory T cells in the peripheral blood of cancer patients with potent immunosuppressive features, which should be considered for the design of immunomodulatory therapies such as dendritic cell vaccination.
Journal Article
Increase of regulatory T cells in the peripheral blood of cancer patients.
Anna Maria Wolf,Dominik Wolf,Michael Steurer,Guenther Gastl,Eberhard Gunsilius,Beatrix Grubeck-Loebenstein +5 more
TL;DR: In this article, the frequency of Tregs in the peripheral blood of 42 patients suffering from epithelial malignancies and from 34 healthy controls was determined by flow cytometry.
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The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer.
Dominik Wolf,Anna Maria Wolf,Holger Rumpold,Heidi Fiegl,Alain G. Zeimet,Elisabeth Müller-Holzner,Martina Deibl,Guenther Gastl,Eberhard Gunsilius,Christian Marth +9 more
TL;DR: High expression levels of FoxP3 might represent a surrogate marker for an immunosuppressive milieu contributing to tumor immune escape and strategies selectively depleting Treg might improve the antitumor activity of endogenously arising tumor-reactive T cells and immunotherapies using vaccines or antibodies.
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Evidence from a leukaemia model for maintenance of vascular endothelium by bone-marrow-derived endothelial cells
Eberhard Gunsilius,Hans-Christoph Duba,AL Petzer,Christian M. Kähler,Kurt Grünewald,G. Stockhammer,Christoph Gabl,Stephan Dirnhofer,Johannes Clausen,Günther Gastl +9 more
TL;DR: The findings suggest that CML is not solely a haematological disease but originates from a bone-marrow-derived haemangioblastic precursor cell that can give rise to both blood cells and endothelial cells, providing a rationale for developing vascular targeting strategies in vasculopathies, inflammatory diseases, and cancer.
Journal ArticleDOI
CD4+CD25+ Regulatory T Cells Inhibit Experimental Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
Dominik Wolf,Kathrin Hochegger,Anna Maria Wolf,Holger Rumpold,Guenther Gastl,Herbert Tilg,Gert Mayer,Eberhard Gunsilius,Alexander R. Rosenkranz +8 more
TL;DR: This report provides first evidence that Treg are potent suppressors of anti-GBM GN and might be of therapeutic value for the treatment of severe GN in humans.