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Alexander R. Rosenkranz
Researcher at Medical University of Graz
Publications - 226
Citations - 5461
Alexander R. Rosenkranz is an academic researcher from Medical University of Graz. The author has contributed to research in topics: Kidney disease & Medicine. The author has an hindex of 33, co-authored 200 publications receiving 4565 citations. Previous affiliations of Alexander R. Rosenkranz include University of Vienna & University of Graz.
Papers
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Journal ArticleDOI
A microplate assay for the detection of oxidative products using 2',7'-dichlorofluorescin-diacetate.
Alexander R. Rosenkranz,Sabine Schmaldienst,Karl M. Stuhlmeier,Wanjun Chen,Walter Knapp,Gerhard J. Zlabinger +5 more
TL;DR: This assay can be useful for screening monoclonal antibodies recognizing cell surface structures possibly involved in signal transduction as well as for testing phagocytes for their capacity to release reactive oxidative intermediates.
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Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
Kathrin Eller,Alexander H. Kirsch,Anna Maria Wolf,Sieghart Sopper,Andrea Tagwerker,Ursula Stanzl,Dominik Wolf,Wolfgang Patsch,Alexander R. Rosenkranz,Philipp Eller +9 more
TL;DR: Data suggest a potential therapeutic value of Tregs to improve insulin resistance and end organ damage in type 2 diabetes by limiting the proinflammatory milieu.
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Chronic kidney disease is a key risk factor for severe COVID-19: a call to action by the ERA-EDTA.
Alberto Ortiz,Mario Cozzolino,Raphaël Duivenvoorden,Danilo Fliser,D. Fouque,Casper F. M. Franssen,D. Goumenos,Marc H Hemmelder,Luuk B. Hilbrands,Kitty J. Jager,Ziad A. Massy,Marlies Noordzij,Alexander R. Rosenkranz,María José Soler,Kathryn K. Stevens,Roser Torra,Serhan Tuglular,Priya Vart,C Wanner,R. T. Gansevoort +19 more
TL;DR: In this paper, the authors defined essential action points (summarized in Box 1), among which is advocating the inclusion of CKD patients in clinical trials testing the efficacy of drugs and vaccines to prevent severe COVID-19.
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A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1 Deficiency Abrogates Sustained Fcγ Receptor–dependent Neutrophil Adhesion and Complement-dependent Proteinuria in Acute Glomerulonephritis
Tao Tang,Alexander R. Rosenkranz,Karel J.M. Assmann,Michael J. Goodman,Jose-Carlos Gutierrez-Ramos,Michael C. Carroll,Ramzi S. Cotran,Tanya N. Mayadas +7 more
TL;DR: It is suggested that in vivo, Mac-1 is not required for the initiation of Fc-mediated PMN recruitment but thatMac-1–FcγR interactions are required for filamentous actin reorganization leading to sustained PMN adhesion, and this represents the first demonstration of the relevance of Mac- 1–F cγR interaction in vivo.
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CD4+CD25+ Regulatory T Cells Inhibit Experimental Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
Dominik Wolf,Kathrin Hochegger,Anna Maria Wolf,Holger Rumpold,Guenther Gastl,Herbert Tilg,Gert Mayer,Eberhard Gunsilius,Alexander R. Rosenkranz +8 more
TL;DR: This report provides first evidence that Treg are potent suppressors of anti-GBM GN and might be of therapeutic value for the treatment of severe GN in humans.