Edgardo Moreno

TL;DR: Examination of the internalization of LPS and its interaction with antigen-presenting major histocompatibility complex (MHC) class II molecules in murine and human B-cell lines raises the possibility that B. abortus LPS may play a role in T-cell activation.

TL;DR: From 46 different hybridomas secreting monoclonal antibodies against various LPS moieties, 9 different specificities were identified and two epitopes, A and C/Y, were present in the O-polysaccharide, which was found in the core oligosaccharide of rough Brucella LPS.

TL;DR: In this paper, the emergence of a novel variant during an outbreak in a Costa Rican hospital that was associated with severe clinical presentations was described, which elicited higher white blood cell counts and caused disease in younger patients than did other strains isolated during the outbreak and had a recurrence rate, a 30-day attributable disease rate and disease severity as great as those of the epidemic strain NAP1.

TL;DR: It can be concluded that BvrR/BvrS influences additional Brucella properties involved in virulence, and the role of group 3 Omps is speculated on.

TL;DR: It is shown for the first time that LPS macrodomains act as detergent resistant membranes (DRMs), segregating several lipid‐raft components, LPS‐binding proteins and MHC‐II molecules.