E
Edgardo Moreno
Researcher at University of Costa Rica
Publications - 145
Citations - 9562
Edgardo Moreno is an academic researcher from University of Costa Rica. The author has contributed to research in topics: Brucella & Brucella melitensis. The author has an hindex of 52, co-authored 139 publications receiving 8784 citations. Previous affiliations of Edgardo Moreno include Karolinska Institutet & University of Navarra.
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Journal ArticleDOI
R-Ras Glucosylation and Transient RhoA Activation Determine the Cytopathic Effect Produced by Toxin B Variants from Toxin A-negative Strains of Clostridium difficile
Esteban Chaves-Olarte,Esteban Chaves-Olarte,Enrique Freer,Andrea Parra,Caterina Guzmán-Verri,Edgardo Moreno,Monica Thelestam +6 more
TL;DR: In this article, it was shown that the cell rounding and detachment mediated by R-Ras glucosylation, and the induction of filopodia-like structures induced by RhoA activation are mediated by C. difficile-induced diarrhea.
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Evaluation of a radial immunodiffusion test with polysaccharide B antigen for diagnosis of bovine brucellosis.
TL;DR: A radial immunodiffusion test employing a polysaccharide antigen (poly B) was compared with tests currently used in the diagnosis of bovine brucellosis and was found to be a very sensitive test which could be useful in areas of low incidence but would not be practical for large-scale testing in adult-vaccinated herds.
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Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2
Carlos Santamaría,Silda Larios,Steve Quiros,Javier Pizarro-Cerdá,Jean-Pierre Gorvel,Bruno Lomonte,Edgardo Moreno +6 more
TL;DR: It is demonstrated that phospholipase A2-derived peptides may have the potential to counteract microbial infections and encourage further evaluations of their actions in vivo.
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Tyr→Trp-substituted peptide 115-129 of a Lys49 phospholipase A2 expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect
TL;DR: The synthetic 13-mer p115-W3 constitutes the first example of a short, PLA(2)-based linear synthetic peptide with the ability to reproduce this effect of a parent protein in vivo, and is in clear support of the proposed relevance of the C-terminal region 115-129 in all the membrane-damaging mechanisms exerted by myotoxin II, including the myotoxic mechanism.