E
Edinson Lucumi
Researcher at Texas A&M University
Publications - 9
Citations - 1134
Edinson Lucumi is an academic researcher from Texas A&M University. The author has contributed to research in topics: Enoyl-acyl carrier protein reductase & Active site. The author has an hindex of 8, co-authored 9 publications receiving 959 citations. Previous affiliations of Edinson Lucumi include University of Pennsylvania & University of Luxembourg.
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Journal ArticleDOI
Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices.
TL;DR: This review outlines some of the advantages and challenges that may accompany a transition from macroscopic to microfluidic cell culture and focuses on decisive factors that distinguish Macroscopic from microfluidity cell culture to encourage a reconsideration of how macroscopy cell culture principles might apply to micro fluidiccell culture.
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Identification of Novel Inhibitors of Dietary Lipid Absorption using Zebrafish
Justin D. Clifton,Edinson Lucumi,Michael C. Myers,Andrew D. Napper,Kotaro Hama,Steven A. Farber,Amos B. Smith,Donna M. Huryn,Scott L. Diamond,Michael Pack +9 more
TL;DR: The feasibility of identifying novel inhibitors of intestinal lipid absorption using the zebrafish system is demonstrated and these findings support the utility of zebra fish screening assays to identify novel compounds that target complex physiological processes.
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Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives.
Joel S. Freundlich,John W. Anderson,Dimitri Sarantakis,Hong Ming Shieh,Min Yu,Juan Carlos Valderramos,Edinson Lucumi,Mack Kuo,William R. Jacobs,David A. Fidock,Guy A. Schiehser,David P. Jacobus,James C. Sacchettini +12 more
TL;DR: X-ray crystal structures of nitro 29, aniline 30, methylamide 37, and urea 46 demonstrate the presence of hydrogen-bonding interactions with residues in the active site and point to future rounds of optimization to improve compound potency against purified enzyme and intracellular parasites.
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Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms
TL;DR: A novel approach to identify antifungal potentiators of clotrimazole is validated and small molecules with activity against C. albicans biofilms are identified, which may specifically target the biofilm and make currently available antIFungals more effective.
Journal ArticleDOI
Discovery of Potent Small-Molecule Inhibitors of Multidrug-Resistant Plasmodium falciparum Using a Novel Miniaturized High-Throughput Luciferase-Based Assay
Edinson Lucumi,Claire Darling,Hyunil Jo,Andrew D. Napper,Rajesh Chandramohanadas,Nicholas Fisher,Alison E. Shone,Huiyan Jing,Stephen A. Ward,Giancarlo A. Biagini,William F. DeGrado,Scott L. Diamond,Doron C. Greenbaum +12 more
TL;DR: It is determined that the new 1,4-napthoquinones act in a novel, non-bc1-dependent mechanism and remain potent against atovaquone- and chloroquine-resistant parasites.