E
Edith M. Hessel
Researcher at GlaxoSmithKline
Publications - 93
Citations - 5248
Edith M. Hessel is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: COPD & Immune system. The author has an hindex of 31, co-authored 89 publications receiving 4499 citations. Previous affiliations of Edith M. Hessel include Covance & Utrecht University.
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Journal ArticleDOI
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.
TL;DR: The identification of the antigen recognition receptors for innate immunity, most notably the Toll-like receptors, has sparked great interest in therapeutic manipulation of the innate immune system and significant efforts have begun to develop antagonists to Toll- like receptors.
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Functions of T cells in asthma: more than just T H 2 cells
Clare M. Lloyd,Edith M. Hessel +1 more
TL;DR: The roles of different T cell subsets in the allergic lung are discussed, how each subset can contribute to the development of allergic pathology is considered and how these cells might be manipulated for new asthma therapies is evaluated.
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Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation
Sigrid R. Ruuls,Robert M. Hoek,Vu N. Ngo,Tom McNeil,Linda Lucian,Mary J Janatpour,Heinrich Körner,Heleen Scheerens,Edith M. Hessel,Jason G. Cyster,Leslie M McEvoy,Jonathon D. Sedgwick +11 more
TL;DR: It is concluded that memTNF supports many processes underlying lymphoid tissue structure, but secreted TNF is needed for optimal inflammatory lesion development.
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Lung inflammation and epithelial changes in a murine model of atopic asthma.
TL;DR: Results indicate that some of the phenotypic changes in airway epithelium that follow an allergic response in the lung can be initiated before the migration of eosinophils or lymphocytes across the epithelial layer.
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PI3K inhibitors in inflammation, autoimmunity and cancer
TL;DR: The role of PI3K signalling in the immune response has been the subject of detailed reviews; here it is focused on relevant recent progress in pre-clinical and clinical development ofPI3K inhibitors.