E
Edmund Tischer
Researcher at University of California, San Francisco
Publications - 23
Citations - 5701
Edmund Tischer is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Gene & Nucleic acid sequence. The author has an hindex of 15, co-authored 23 publications receiving 5650 citations. Previous affiliations of Edmund Tischer include Harvard University.
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Journal ArticleDOI
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.
Edmund Tischer,R. Mitchell,T. Hartman,M. Silva,Denis Gospodarowicz,J.C. Fiddes,Judith A. Abraham +6 more
TL;DR: This article showed that VEGF is produced by cultured vascular smooth muscle cells by polymerase chain reaction and cDNA cloning, and showed that the three forms of the human vascular endothelial growth factor (VEGF) protein chain predicted from these coding regions are 189, 165, and 121 amino acids in length.
Journal ArticleDOI
Rat Insulin Genes: Construction of Plasmids Containing the Coding Sequences
Axel Ullrich,John Shine,Chirgwin John Mitchell,Raymond Pictet,Edmund Tischer,William J. Rutter,Howard M. Goodman +6 more
TL;DR: Recombinant bacterial plasmids have been constructed that contain complementary DNA prepared from rat islets of Langerhans messenger RNA that contain cloned sequences representing the complete coding region of rat proinsulin I, part of the preproinsulin II prepeptide, and the untranslated 3' terminal region of the mRNA.
Journal ArticleDOI
Sequence of the human insulin gene
Graeme I. Bell,Raymond Pictet,William J. Rutter,Barbara Cordell,Edmund Tischer,Howard M. Goodman +5 more
TL;DR: A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA segment preceding the gene and suggests that the ancestral form of the insulin gene had two intervening sequences.
Patent
Production of vascular endothelial cell growth factor
TL;DR: In this paper, an isolated vascular endothelial cell growth factor selected from the group consisting of bovine VEGF of 120 amino acids and human vascular endothelia growth factor of 121 amino acids is described.
Journal ArticleDOI
Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family.
Edmund Tischer,Denis Gospodarowicz,Richard Mitchell,Maria Elena Silva,James W. Schilling,Kenneth K. Lau,Tracey Crisp,John C. Fiddes,Judith A. Abraham +8 more
TL;DR: Analysis of the clones indicates that bovine vascular endothelial growth factor can exist in two forms, probably due to alternative RNA splicing, and shows that VEGF shares homologies of about 21% and 24% respectively with the A and B chains of human platelet-derived growth factor (PDGF).