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Graeme I. Bell

Researcher at University of Chicago

Publications -  532
Citations -  63504

Graeme I. Bell is an academic researcher from University of Chicago. The author has contributed to research in topics: Gene & Insulin. The author has an hindex of 127, co-authored 531 publications receiving 61011 citations. Previous affiliations of Graeme I. Bell include French Institute of Health and Medical Research & University of California.

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Journal ArticleDOI

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

Kazuya Yamagata, +9 more
- 05 Dec 1996 - 
TL;DR: It is shown that subjects with the MODY3-form of NIDDM have mutations in the gene encoding hepatocyte nuclear factor-1α (HNF-1 α), which is encoded by the gene TCF1, which is a transcription factor that helps in the tissue-specific regulation of the expression of several liver genes.
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Yukio Horikawa, +28 more
- 01 Oct 2000 - 
TL;DR: The positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland is described, suggesting a novel pathway that may contribute to the development of type 1 diabetes.
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Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

Duncan T. Odom, +12 more
- 27 Feb 2004 - 
TL;DR: This work used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1α, HNF4α, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets.
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Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young

Stefan S. Fajans, +2 more
- 27 Sep 2001 - 
TL;DR: Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of inheritance, an onset usually before the age of 25 years and frequently in childhood or adolescence, and a primary defect in the function of the beta cells of the pancreas.
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Anubha Mahajan, +395 more
- 01 Mar 2014 - 
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.