J
Judith A. Abraham
Researcher at Boston Children's Hospital
Publications - 50
Citations - 11001
Judith A. Abraham is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Growth factor & Heparin-binding EGF-like growth factor. The author has an hindex of 34, co-authored 50 publications receiving 10914 citations. Previous affiliations of Judith A. Abraham include Osaka University & University of Washington.
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The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.
Edmund Tischer,R. Mitchell,T. Hartman,M. Silva,Denis Gospodarowicz,J.C. Fiddes,Judith A. Abraham +6 more
TL;DR: This article showed that VEGF is produced by cultured vascular smooth muscle cells by polymerase chain reaction and cDNA cloning, and showed that the three forms of the human vascular endothelial growth factor (VEGF) protein chain predicted from these coding regions are 189, 165, and 121 amino acids in length.
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A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.
TL;DR: This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smoother muscle cells than is EGF.
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Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor.
Judith A. Abraham,Ayalew Mergia,Jacqueline L. Whang,Annette Tumolo,Jeffrey M. Friedman,Kathryn A. Hjerrild,Denis Gospodarowicz,John C. Fiddes +7 more
TL;DR: An oligonucleotide probe was designed from the nucleotide sequence of the amino-terminal exon of bovine acidic FGF, taking into account the 55 percent amino acid sequence homology between the two factors.
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Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth
Lothar Schweigerer,Gera Neufeld,Jeffrey M. Friedman,Judith A. Abraham,John C. Fiddes,Denis Gospodarowicz +5 more
TL;DR: It is concluded that basic fibroblast growth factor (bFGF) can act as a self-stimulating growth factor for capillary endothelial cells, and that it is possible that the formation of new capillaries is induced by capillary vascularized cells themselves.
Journal ArticleDOI
Human basic fibroblast growth factor: nucleotide sequence and genomic organization.
Judith A. Abraham,J.L. Whang,Annette Tumolo,Ayalew Mergia,Jeffrey M. Friedman,Denis Gospodarowicz,John C. Fiddes +6 more
TL;DR: Southern blot analysis of human genomic DNA and mapping of the cloned gene shows that there is only one basic FGF gene, and all of the basic, heparin‐binding endothelial cell mitogens of similar amino acid composition that have been described must be products of this single gene.