Edon Melloni

TL;DR: Protection against nigral neuron degeneration in PD may be sufficient to facilitate normalized locomotor activity without necessitating striatal reinnervation, according to the results of a mouse model of PD.

TL;DR: HMGB1 exerts proangiogenic effects by inducing MAPK ERK1/2 activation, cell proliferation, and chemotaxis in endothelial cells of different origin by inhibits HMGB1-induced neovascularization in vivo and endothelial cell proliferation and membrane ruffling in vitro.

TL;DR: In the presence of micromolar concentrations of Ca2+, both protein kinase C and a cytosolic Ca2+-requiring neutral proteinase of human neutrophils become associated with the neutrophil membrane and may have access, in the intact cell, to intracellular protein substrates.

TL;DR: The degradation of troponin (Tn) subunits by calpain was studied by incubating either isolated cardiac Tns or myocardial cryosections with two different calpain isoenzymes isolated from rat skeletal muscle and showed that mu-calpain was at least ten times more active than m-Calpain in degrading TnI and TnT both in vitro and in situ.

TL;DR: This study is the first to suggest that HMGB1/astrocyte interaction plays a specific functional role in the progression of inflammatory processes in the CNS by facilitating local leukocyte infiltration.