E
Edward A. Meighen
Researcher at McGill University
Publications - 124
Citations - 4680
Edward A. Meighen is an academic researcher from McGill University. The author has contributed to research in topics: Vibrio harveyi & Luciferase. The author has an hindex of 38, co-authored 124 publications receiving 4548 citations. Previous affiliations of Edward A. Meighen include Institut national de la recherche scientifique & Simon Fraser University.
Papers
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Journal ArticleDOI
Purification and structural identification of an autoinducer for the luminescence system of Vibrio harveyi.
Jie-Gang Cao,Edward A. Meighen +1 more
TL;DR: The similarity in structure of the autoinducer of V. harveyi to that of Vibrio fischeri suggests that the regulation of luminescence induction in these bacteria may be related in spite of their differences in lux gene organization.
Journal ArticleDOI
Bacterial bioluminescence: organization, regulation, and application of the lux genes
TL;DR: Isolation of the lux genes and the ability to transfer these genes into prokaryotic and eukaryotic organisms have greatly expanded the scope and potential uses of bacterial bioluminescence as a safe, rapid, and sensitive sensor for a wide variety of compounds and metabolic processes.
Journal ArticleDOI
The natural furanone (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone disrupts quorum sensing-regulated gene expression in Vibrio harveyi by decreasing the DNA-binding activity of the transcriptional regulator protein luxR
Tom Defoirdt,Carol M. Miyamoto,Thomas K. Wood,Edward A. Meighen,Patrick Sorgeloos,Willy Verstraete,Peter Bossier +6 more
TL;DR: The data indicate that the furanone blocks quorum sensing in V. harveyi by rendering the quorum Sensing master regulator protein LuxR(Vh) unable to bind to the promoter sequences ofQuorum sensing-regulated genes.
Journal ArticleDOI
Nucleotide sequence, expression, and properties of luciferase coded by lux genes from a terrestrial bacterium.
Rose Szittner,Edward A. Meighen +1 more
TL;DR: Results indicate that the X. luminescens lux system may be the bacterial bioluminescent system of choice for application in coupled luminescent assays and expression of lux genes in eukaryotic systems at higher temperatures.
Book ChapterDOI
Physiological, biochemical and genetic control of bacterial bioluminescence.
Edward A. Meighen,Paul V. Dunlap +1 more
TL;DR: This chapter describes the current status of bioluminescent systems of luminous bacteria, emphasizing the biochemistry, lux gene organization, and the physiological and genetic regulation of lux gene expression.