E
Edward F. Fritsch
Researcher at Harvard University
Publications - 27
Citations - 218491
Edward F. Fritsch is an academic researcher from Harvard University. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 13, co-authored 24 publications receiving 217950 citations. Previous affiliations of Edward F. Fritsch include Brigham and Women's Hospital & California Institute of Technology.
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Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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The Isolation and Characterization of Linked δ- and β-Globin Genes from a Cloned Library of Human DNA
TL;DR: The two independently isolated β-globin clones differ from each other by the presence of a Pst I restriction enzyme cleavage site within the large intervening sequence of the δ- globin gene of one of the clones, which suggests that the human DNA carried in the two clones was derived from two homologous chromosomes which were heterozygous for the PstI restriction enzyme recognition sequence.
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Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial
Derin B. Keskin,Annabelle J. Anandappa,Jing Sun,Itay Tirosh,Nathan Mathewson,Shuqiang Li,Giacomo Oliveira,Anita Giobbie-Hurder,Kristen Felt,Evisa Gjini,Sachet A. Shukla,Zhuting Hu,Letitia Li,Phuong M. Le,Rosa Lundbye Allesøe,Rosa Lundbye Allesøe,Alyssa R. Richman,Monika S. Kowalczyk,Sara Abdelrahman,Jack Geduldig,Sarah Charbonneau,Kristine Pelton,J. Bryan Iorgulescu,Liudmila Elagina,Wandi Zhang,Oriol Olive,Christine McCluskey,Lars Rønn Olsen,Jonathan Stevens,William J. Lane,Andres M. Salazar,Heather Daley,Patrick Y. Wen,E. Antonio Chiocca,Maegan Harden,Niall J. Lennon,Stacey Gabriel,Gad Getz,Eric S. Lander,Aviv Regev,Jerome Ritz,Donna Neuberg,Scott J. Rodig,Keith L. Ligon,Mario L. Suvà,Kai W. Wucherpfennig,Nir Hacohen,Edward F. Fritsch,Kenneth J. Livak,Patrick A. Ott,Catherine J. Wu,David A. Reardon +51 more
TL;DR: It is demonstrated that a strategy that uses multi-epitope, personalized neoantigen vaccination, which has previously been tested in patients with high-risk melanoma, is feasible for tumours such as glioblastoma, which typically have a relatively low mutation load and an immunologically ‘cold’ tumour microenvironment.
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Molecular cloning and characterization of the human β-like globin gene cluster
TL;DR: The genes encoding human embryonic (epsilon), fetal (G gamma, A gamma) and adult (delta, beta) beta-like globin polypeptides were isolated as a set of overlapping cloned DNA fragments from bacteriophage lambda libraries of high molecular weight (15-20 kb) chromosomal DNA as discussed by the authors.
Journal ArticleDOI
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.
Mohini Rajasagi,Sachet A. Shukla,Edward F. Fritsch,Derin B. Keskin,David S. DeLuca,Ellese M. Carmona,Wandi Zhang,Carrie Sougnez,Kristian Cibulskis,John Sidney,Kristen E. Stevenson,Jerome Ritz,Jerome Ritz,Donna Neuberg,Vladimir Brusic,Stacey Gabriel,Eric S. Lander,Gad Getz,Gad Getz,Nir Hacohen,Nir Hacohen,Catherine J. Wu,Catherine J. Wu +22 more
TL;DR: A streamlined approach for the prediction and validation of neoantigens derived from individual tumors and presented by patient-specific HLA alleles is implemented, suggesting that neoantIGens are frequent in most tumors.