E
Edward H. Cohen
Researcher at Commonwealth Scientific and Industrial Research Organisation
Publications - 6
Citations - 149
Edward H. Cohen is an academic researcher from Commonwealth Scientific and Industrial Research Organisation. The author has contributed to research in topics: Binding site & Phage display. The author has an hindex of 5, co-authored 6 publications receiving 145 citations.
Papers
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Journal ArticleDOI
AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes
Motomu Shimaoka,Minsoo Kim,Edward H. Cohen,Wei Yang,Nathan S. Astrof,Dan Peer,Azucena Salas,Audrey Ferrand,Timothy A. Springer +8 more
TL;DR: Monovalent Fab AL-57 demonstrates affinity increases on a subset of lymphocyte cell surface LFA-1 molecules upon stimulation with CXCL-12 (CXC chemokine ligand 12).
Journal ArticleDOI
A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo
Daniel T. Dransfield,Edward H. Cohen,Qing Chang,Lindsay G. Sparrow,John D. Bentley,Olan Dolezal,Xiaowen Xiao,Thomas S. Peat,Janet Newman,Patricia A. Pilling,Tram Phan,Ilka Priebe,Gemma V. Brierley,Niksa Kastrapeli,Kris Kopacz,Diana Martik,Dina Wassaf,Douglas Rank,Greg Conley,Yan Huang,Timothy E. Adams,Leah J. Cosgrove +21 more
TL;DR: DX-2647 inhibited IGF-II and, to a lesser extent, IGF-I–induced receptor tyrosine phosphorylation, cellular proliferation, and both anch Anchorage-dependent and anchorage-independent colony formation in various cell lines.
Journal ArticleDOI
Oligonucleotide-assisted cleavage and ligation: a novel directional DNA cloning technology to capture cDNAs. Application in the construction of a human immune antibody phage-display library
Sonia Schoonbroodt,Nicolas Frans,Mark DeSouza,Rachel Eren,Smadar Priel,Naama Brosh,Judith Ben-Porath,Arie Zauberman,Ehud Ilan,Shlomo Dagan,Edward H. Cohen,Hennie R. Hoogenboom,Robert Charles Ladner,Rene Hoet +13 more
TL;DR: Full representation of all VH families/segments was observed showing that ONCL did not introduce cloning biases for or against any VH family, and the efficiency of ONCL was validated by creating a functional Fab phage-display library with a size of 3.3 × 1010 and by selecting five unique Fabs against GAPDH antigen.
Journal ArticleDOI
Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1
Lili Huang,Motomu Shimaoka,Isaac J. Rondon,Illa Roy,Qing Chang,Melody Po,Daniel T. Dransfield,Robert Charles Ladner,Albert S.B. Edge,Azucena Salas,Clive R. Wood,Timothy A. Springer,Edward H. Cohen +12 more
TL;DR: Results indicate that specifically targeting the HA I domain is sufficient to inhibit LFA‐1‐mediated, adhesive functions, and represents a therapeutic candidate for treatment of inflammatory and autoimmune diseases.
Patent
Igf-ii/gf-iie binding proteins
TL;DR: In this paper, proteins that bind to IGF-II and/or FGIIE and methods of using such proteins are described and new methods for treatment of cancer are new methods are presented.