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Edyta M. Grzelak
Researcher at University of Illinois at Chicago
Publications - 18
Citations - 706
Edyta M. Grzelak is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Flumequine & High-performance liquid chromatography. The author has an hindex of 11, co-authored 18 publications receiving 536 citations. Previous affiliations of Edyta M. Grzelak include Scripps Research Institute.
Papers
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Journal ArticleDOI
Bioautography detection in thin-layer chromatography
Irena M. Choma,Edyta M. Grzelak +1 more
TL;DR: The review discusses three versions of bioautography, i.e. contact, immersion and direct bioautographic, and the most promising among them seems to be TLC-bioluminescence screening.
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QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity.
Marcelo N. Gomes,Rodolpho C. Braga,Edyta M. Grzelak,Bruno J. Neves,Eugene N. Muratov,Rui Ma,Larry L. Klein,Sang-Hyun Cho,Guilherme R. Oliveira,Scott G. Franzblau,Carolina Horta Andrade +10 more
TL;DR: The results suggest that the designed heteroaryl chalcone compounds, due to their high potency and selectivity, are promising anti-TB agents.
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Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
Mary P. Choules,Nina M. Wolf,Hyun Lee,Jeffrey R. Anderson,Edyta M. Grzelak,Yuehong Wang,Rui Ma,Wei Gao,James B. McAlpine,Ying Yu Jin,Jinhua Cheng,Hanki Lee,Joo Won Suh,Nguyen Minh Duc,Seungwha Paik,Jin Ho Choe,Eun-Kyeong Jo,Chulhun L. Chang,Jong-Seok Lee,Birgit U. Jaki,Guido F. Pauli,Scott G. Franzblau,Sang-Hyun Cho +22 more
TL;DR: Rufomycin I (RUFI) was found to be a potent and selective lead compound for both M. tuberculosis and Mycobacterium abscessus, providing evidence that although these peptides share ClpC1 as a macromolecular target, their downstream effects are distinct, likely due to differences in binding.
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Quechers methodologies as an alternative to solid phase extraction (SPE) for the determination and characterization of residues of cephalosporins in beef muscle using LC-MS/MS.
TL;DR: This work was focused on the comparison of two clean-up methods to be used for the simultaneous determination of seven cephalosporins in cow muscle by assessing the performance of novel dispersive solid phase extraction procedures based on QuEChERS methodologies and conventional SPE.
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Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening.
Edyta M. Grzelak,Mary P. Choules,Wei Gao,Geping Cai,Baojie Wan,Yuehong Wang,James B. McAlpine,Jinhua Cheng,Ying-Yu Jin,Hanki Lee,Joo Won Suh,Guido F. Pauli,Scott G. Franzblau,Birgit U. Jaki,Sang-Hyun Cho +14 more
TL;DR: Recent high-throughput phenotypic screening strategies for anti-M.