E
Eileen Gentleman
Researcher at King's College London
Publications - 73
Citations - 4919
Eileen Gentleman is an academic researcher from King's College London. The author has contributed to research in topics: Self-healing hydrogels & Tissue engineering. The author has an hindex of 29, co-authored 66 publications receiving 4026 citations. Previous affiliations of Eileen Gentleman include Imperial College London & Royal School of Mines.
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Journal ArticleDOI
The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro
Eileen Gentleman,Yann C. Fredholm,Gavin Jell,Nasrin Lotfibakhshaiesh,M.D. O’Donnell,Robert G. Hill,Molly M. Stevens +6 more
TL;DR: It is shown that ions released from strontium-substituted BG enhance metabolic activity in osteoblasts and inhibit osteoclast activity by both reducing tartrate resistant acid phosphatase activity and inhibiting resorption of calcium phosphate films in a dose-dependent manner.
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Substrate stiffness affects early differentiation events in embryonic stem cells.
Nicholas D. Evans,Caterina Minelli,Eileen Gentleman,Vanessa L.S. LaPointe,Sameer N. Patankar,Maria Kallivretaki,Xinyong Chen,Clive J. Roberts,Molly M. Stevens +8 more
TL;DR: A fundamental role for mechanosensing in mammalian development is suggested and the mechanical environment should be taken into consideration when engineering implantable scaffolds or when producing therapeutically relevant cell populations in vitro is illustrated.
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The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation
Suwimon Boonrungsiman,Eileen Gentleman,Raffaella Carzaniga,Nicholas D. Evans,David W. McComb,Alexandra E. Porter,Molly M. Stevens +6 more
TL;DR: A sample-preparation method that simultaneously preserved mineral, ions, and ECM with nano-analytical electron microscopy techniques to examine osteoblasts in an in vitro model of bone formation identified calcium phosphate both within osteoblast mitochondrial granules and intracellular vesicles that transported material to the ECM.
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Mechanical characterization of collagen fibers and scaffolds for tissue engineering.
TL;DR: Mechanical properties of collagen as a scaffolding biomaterial for ligament replacements for tissue-engineered products must possess appropriate mechanical as well as biological/chemical properties should help enable the development of improved tissue analogues.
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Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification.
Sergio Bertazzo,Eileen Gentleman,Eileen Gentleman,Kristy L. Cloyd,Adrian H. Chester,Magdi H. Yacoub,Molly M. Stevens +6 more
TL;DR: Using nano-analytical electron microscopy techniques, valves, aortae and coronary arteries from patients with and without calcific cardiovascular disease are examined and spherical calcium phosphate particles are detected, regardless of the presence of calcific lesions, suggesting mineralized spherical particles may play a fundamental role in calcific lesion formation.