Eileen Gentleman

TL;DR: This review will summarise the evolution of materials for investigating cell and tissue mechanobiology, and discuss how material properties such as elastic modulus may be interpreted, particularly with regard to analytic measurements as an approximation of how cells themselves sense elasticModulus.

TL;DR: The results support the promise of collagen composites as a biomaterial for use in producing soft tissues in vitro by supporting cell-mediated contraction in constructs seeded with preadipocytes.

TL;DR: As an intermediary between cells and scaffolding biomaterials, the extracellular matrix secreted by the cells offers challenges and opportunities for the design and fabrication of engineered tissues.

TL;DR: The unexpected findings of this strong metabolic pathway regulation as a response to biomaterial composition highlight the benefits of discovery-driven nonreductionist approaches to gain a deeper understanding of global cell–material interactions and suggest alternative research routes for evaluating biomaterials to improve their design.

TL;DR: Gut organoid cocultures with type-1 innate lymphoid cells (ILC1) with MMP-sensitive, synthetic hydrogels designed to form efficient networks at low polymer concentrations are developed to elucidate previously undescribed interactions between ILC1 and their microenvironment, which suggest that they may exacerbate fibrosis and tumour growth when enriched in inflamed patient tissues.